MicroRNA与血管内皮细胞功能调节机制进展  

Research Progress of Adjustment Mechanism between MicroRNA and Vascular Endothelial Cell Function

作　　者：张磊[1] 王春[1] 

机构地区：[1]中国医科大学附属第一医院心脏外科,沈阳110001

出　　处：《中国胸心血管外科临床杂志》2016年第3期299-303,共5页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：2015年辽宁省自然科学基金面上项目(2015020498)~~

摘　　要：血管内皮细胞(vascular endothelial cell,VEC)是衬于血管内表面的单层扁平上皮细胞,是血液与组织的之间的重要屏障。它在调节炎症反应,血栓形成,内皮细胞介导的血管舒张,内皮再生等病理生理过程中起关键作用,这些过程受到多种复杂机制的调控。随着人们对于血管内皮细胞功能研究的深入,micro RNA在内皮细胞发挥其功能时的调控作用受到越来越多的关注。多种micro RNA可在转录后水平调控基因表达,影响内皮细胞的功能,本文对micro RNA在内皮细胞炎症反应、血栓形成、血管舒张、内皮再生功能的调节机制进行综述。Vascular endothelial cell（VEC） is a kind of simple squamous epithelium lined on the inner surface of blood vessels. VEC is an important barrier between the blood and tissue and it also plays a key role in regulating inflammation, thrombosis, endothelial cells mediated vasodilatation and endothelial regeneration. These processes should be controlled by a variety of complex mechanism which requires us to find out. With results of the researches in vascular endothelial cell function, the important roles that microRNA in vascular endothelial cell function draws more and more researchers＇ attention. MicroRNAs control gene expression in post-transcriptional level and affect the function of endothelial cells. This review focuses on the research progress on regulatory mechanism of microRNA to endothelial cell inflammation, thrombosis, vasodilation and endothelium regeneration.

关 键 词：血管内皮细胞 Micro RNA 炎症反应 动脉粥样硬化 内皮修复 

分 类 号：R54[医药卫生—心血管疾病]