N-(5-苯基-1,3,4-噻二唑-2-基)-N′-氯代苯基脲类化合物的合成  

Synthesis of N-(5-Phenyl-1,3,4-thiadiazol-2-yl)-N′-chlorophenylureas

作　　者：童国通[1] 吕路平[1] 周小锋[1] 李巍巍[1] 

机构地区：[1]杭州职业技术学院,浙江杭州310018

出　　处：《化学世界》2016年第2期110-112,117,共4页Chemical World

基　　金：杭州市属高校绿色精细化工研究与技术转化重点实验室研究项目(HZJ2013-05)

摘　　要：2-氨基-5-苯基-1,3,4-噻二唑与氯代苯异氰酸酯反应合成了5种N-（5-烷基-1,3,4-噻二唑-2-基）-N′-取代苯基脲,产率为75%~82%。用核磁共振氢谱、红外光谱和元素分析确证了目标化合物的结构,初步的生物活性测定试验表明,该系列化合物具有一定的生物活性。Five novel chlorinated phenylureas were synthesized from chlorinated isocyanates with 2-amino- 5-phenyl-1,3,4-thiadiazoles,which were prepared by one-pot procedure. The total yields of the title com- pounds were 75~82%. The structures of these compounds were confirmed by IR,^1H NMR and elemen- tal analysis. The preliminary biological activity tests showed that these compounds exhibited some plant- growth regulating activity.

关 键 词：噻二唑 苯基脲 合成 生物活性 

分 类 号：O625.6[理学—有机化学]