米可定泡腾片联合伊曲康唑胶囊治疗复发性念珠菌性阴道炎效果评价  

The Effect Assessment of Nystain Effervescent Tablets Combined with Itraconazole Capsules to Therapy Recurrent Vaginal Yeast Infection

作　　者：江丽瑜 

机构地区：[1]广东省揭阳市慈云医院,广东揭阳522031

出　　处：《中国医学创新》2016年第4期20-22,共3页Medical Innovation of China

基　　金：广东省揭阳市市级立项(44011120150134K)

摘　　要：目的:探讨米可定泡腾片联合伊曲康唑胶囊治疗复发性念珠菌性阴道炎的临床效果。方法:选取本院2011年1月-2013年12月收治的复发性念珠菌性阴道炎患者300例,按随机数字表法将纳入病例分为观察组和对照组,每组150例。对照组患者采用阴道内置米可定泡腾片治疗,观察组患者采取口服伊曲康唑胶囊0.2 g/d联合内置米可定泡腾片治疗,7 d为1个疗程,治疗6个疗程。观察6个疗程结束后,两组患者的临床疗效、瘙痒缓解时间以及复发情况。结果:两组患者治疗后,观察组总有效率为94.67%,瘙痒缓解时间为(14.8±3.2)d;对照组总有效率为86.67%,瘙痒缓解时间为(24.2±4.5)d,观察组总有效率明显高于对照组,瘙痒缓解时间明显低于对照组,两组比较差异均有统计学意义(P<0.05)。观察组在治疗后8周和12周复发病例均少于对照组,两组比较差异有统计学意义(P<0.05)。结论:采用米可定泡腾片联合伊曲康唑胶囊口服治疗复发性念珠菌性阴道炎,其临床疗效明显优于米可定泡腾片单药应用,值得临床推广。Objective： To study the clinical effect of nystain effervescent tablets combined with itraconazole capsules to therapy recurrent vaginal yeast infection. Method： 300 patients with recurrent vaginal yeast infection were selected from January 2011 to December 2013 in our hospital, according to random number table method, all the patients were divided into observation group and control group, each group contained 150 cases. The control group was given nystain effervescent tablets and the observation group was given itraconazole capsule combined with nystain effervescent tablets to therapy recurrent recurrent vaginal yeast infection, the treatment include 6 courses and 7 days for a period of treatment. After 6 courses, clinical efficacy, itch relief time and recurrence between the two groups were observed. Result： After treatment, total effective rate of the observation group was 94.67%, itch relief time was （ 14.8 ＋ 3.2 ） d, and those of the control group were 86.67% and （ 24.2 ＋ 4.5 ） d, respectively, total effective rate of the observation group was significantly higher than that of the control group, but itch relief time was lower, the differences were statistically significant （P〈0.05） . After 8 and 12 weeks treatment, the recurrence cases of the observation group were lower than those of the control group, the differences were statistically significant （ P〈0.05 ） . Conclusion： Nystain effervescent tablets combined with itraconazole capsules to therapy recurrent vaginal yeast infection superior to the nystain effervescent tablets, is worthy of clinical popularization and application.

关 键 词：复发性念珠菌性阴道炎 米可定泡腾片 伊曲康唑 

分 类 号：R711.31[医药卫生—妇产科学]