凝血因子11基因rs2289252和rs2036914多态性与静脉血栓栓塞症易感性关系的Meta分析  

The correlation between the polymorphism of coagulation factor XI gene rs2289252 and susceptibility of rs2036914 and venous thromboembolism ： a Meta-analysis

作　　者：张建敏[1] 马信龙[1] 马剑雄[1] 王涛[1] 孙晓雷[1] 田爱现 王颖[1] 孙磊[1] 王建宝[1] 卢斌[1] 姜宏强 

机构地区：[1]天津市天津医院骨科研究所,天津300211

出　　处：《中国中西医结合急救杂志》2016年第1期31-35,共5页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：国家自然科学基金资助项目（81572154）

摘　　要：目的用Meta分析方法评价凝血因子Ⅺ（F11）基因rs2289252位点和rs2036914位点多态性与静脉血栓栓塞症（VTE）易感性的关系。方法通过计算机检索美国国立医学图书馆PubMed、Cochrane临床试验数据库、荷兰医学文摘EMBASE、中国生物医学文献数据库（CBM）、万方数据库、中国知网数据库CNKI及谷歌学术文献检索平台上所有关于F11基因rs2289252位点和rs2036914位点多态性与VTE易感性关系的病例对照研究，检索时间为建库至2015年7月。以研究组和对照组rs2289252位点和rs2036914位点各种基因模型的优势比（OR）及95％可信区间（95％CI）为效应指标，采用Stata12．0软件进行Meta分析，评价rs2289252、rs2036914基因多态性与VTE的关系，并绘制漏斗图评估发表偏倚。结果共纳人9篇文献的14个研究，其中8篇文献的9个研究是关于rs2289252多态性与VTE的关系，4篇文献的5个研究是关于rs2036914与VTE的关系。Meta分析显示：rs2289252多态性与VTE易感性有关，其中：等位基因模型（T比C）：OR=1．32，95％CI=1．26～1．38，P〈0．001，表明等位基因T携带者能增加VTE的发病风险；显性遗传模型（1Tr＋cT比cc）：OR=1．49，95％C／=1．37—1．61，P〈0．001；隐性遗传模型（’rT比CC＋CT）：OR=1．51，95％C／=1．38～1．65，P〈0．001：纯合子比较模型（rrrr比cc）：OR=1．83，95％CI=1．65～2．03，P〈0．001；杂合子比较模型（cT比CC）：OR=1．37，95％CI=1．26-1．49，P〈0．001]。rs2036914多态性与VTE易感性有关，其中：等位基因模型（c比T）：OR=1．28，95％CI=1．22—1．34，P〈0．001，表明等位基因c携带者能增加VTE的发病风险；显性遗传模型（CC＋CT比TT）：OR=1．49，95％C／=1．36～1．64，P〈0．001；隐性遗传模型（CC比CT＋TT）：OR=1．41，95％C／=1.31—1．53，JP〈0．001；纯合子比较模型（CC比TT）：OR=1．75，95％CI=1．57～1．94，P�Objective To evaluate the relationship between the polymorphism of coagulation factor XI gene （Fll） rs2289252 and rs2036914 loci and susceptibility of venous thromboembolism （VTE） via Meta- analysis. Methods A computer retrieval was carried out in American National Library to collect the case-control studies related to the association between the locus polymorphism of Fll gene rs2289252 and rs2036914 and the susceptibility of VTE from PubMed, Cochrane Library, EMBASE, Chinese biological and medical database （CBM）, Wanfang, China National Knowledge Infrastructure （CNKI） and Google Scholar from their data establishment to July 2015. The pooled odds ratio （OR） and corresponding 95% confidence interval （95%@ of various gene models of rs2289252, rs2036914 loci in research and control groups were used as the effective indexes to assess the strength of the association, Statal2.0 soft ware was utilized for Meta analysis to evaluate the relationship between rs2289252 or rs2036914 gene polymorphism and VTE, and funnel plots were applied to assess the publication biases. Results A total of 14 case-control studies from 9 literatures were included. Among them ~ studies from 8 literatures were analyzed for the relationship between rs2289252 polymorphism and VTE and the other 5 studies from 4 literatures were analyzed for the relationship between rs2036914 polymorphism and VTE. The results of Meta-analysis showed that there was correlation between genetic polymorphism of rs2289252 and VTE [allele model （T vs. C）： OR = 1.32, 95%CI = 1.26 - 1.38, P 〈 0.001], which indicated that allele T carriers could increase the risk of the VTE incidence. Dominant hereditary model （TT＋CT vs. CC）： OR = 1.49, 95%CI = 1.37 - 1.61, P 〈 0.001; recessive hereditary model （TT vs. CC＋CT）： OR = 1.51, 95%CI = 1.38 - 1.65, P 〈 0.001; homozygous model （TT vs. CC）： OR = 1.83, 95%CI = 1.65 - 2.03, P 〈 0.001; heterozygous model （CT vs. CC）： OR = 1.37, 95%CI = 1.26 - 1.49, P 〈 0.001]. There was

关 键 词：凝血因子Ⅺ 静脉血栓栓塞症 深静脉血栓 基因多态性 易感性 META分析 

分 类 号：R195.1[医药卫生—卫生统计学]