美托洛尔联合丹参多酚酸盐对老年冠心病心绞痛病人血脂、超敏C-反应蛋白的影响  

Effects of Metoprolol and Salvianolate on Blood Lipids and High-sensitivity C-Reactive Protein in Elderly Coronary Artery Disease Patients with Angina Pectoris

作　　者：陈灏璟 张睿[2] 龚和禾[1] 

机构地区：[1]南京医科大学附属南京医院,南京市第一医院,南京210006 [2]江苏省中医院

出　　处：《中西医结合心脑血管病杂志》2016年第3期250-253,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨美托洛尔联合丹参多酚酸盐对老年冠心病心绞痛病人血脂、超敏C-反应蛋白的影响。方法 98例病人根据随机数字表法随机分为观察组和对照组,各49例。两组均给予常规治疗。对照组给予美托洛尔治疗,观察组在对照组基础上结合丹参多酚酸盐治疗。两组疗程均为14d。对比分析两组病人治疗后临床疗效、心绞痛发作时间和持续时间,治疗前后血脂水平和超敏C-反应蛋白(hs-CRP)水平。结果观察组治疗后总有效率(91.84%)显著高于对照组(75.51%),差异有统计学意义(P<0.05);治疗后观察组心绞痛发作时间和持续时间显著低于治疗前及同期对照组,且具有统计学意义(P<0.05);治疗后观察组TC、TG、LDL-C水平显著低于治疗前及同期对照组,高密度脂蛋白胆固醇(HDL-C)水平显著高于治疗前及同期对照组(P<0.05);治疗后观察组hs-CRP水平显著低于治疗前及同期对照组(P<0.05);两组病人治疗过程中均未发生明显不良反应。结论美托洛尔联合丹参多酚酸盐对老年冠心病心绞痛病人治疗效果显著,可明显改善病人血脂和超敏C-反应蛋白水平。Objective To investigate the effects of metoprolol and salvianolate on blood lipids and high-sensitivity C-reactive protein（hs-CRP）in elderly patients with angina pectoris.Methods Ninety-eight patients with angina pectoris were randomly divided into two groups according to a random number table：Control group（n =49）treated by metoprolol and observation group（n =49）treated by metoprolol plus salvianolate on the basis of conventional treatment for 14 days.The clinical efficacy,onset time and duration of angina pectoris,the levels of blood lipids and hs-CRP were observed.Results The total clinical effective rate was 91.84%in observation group,which was higher than that in control group（75.51%,P 〈0.05）.The onset time and duration of angina pectoris in observation group after treatment were significantly lower than that before treatment and control group（P 〈0.05）.The levels of total cholesterol,triglyceride and low-density lipoprotein-cholesterol in observation group after treatment were significantly lower than that before treatment and control group（P 〈0.05）.The levels of high-density lipoprotein-cholesterol were significantly higher than that before treatment and control group（P 〈0.05）.The levels of hs-CRP levels was significantly lower than that before treatment and control group（P 〈0.05）.There was no adverse reactions in two groups.Conclusion Metoprolol and salvianolate has obvious therapeutic effect on elderly patients with angina pectoris,which can significantly improve blood lipids and hs-CRP levels.

关 键 词：冠心病心绞痛 胸痹 美托洛尔 丹参多酚酸盐 血脂 超敏C-反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]