无创正压通气联合纳洛酮治疗慢性阻塞性肺疾病急性加重期并发Ⅱ型呼吸衰竭的临床研究  

Clinical study on non-invasive positive pressure ventilation combined with naloxone in the treatment of acute exacerbation of chronic obstructive pulmonary disease complicated with type Ⅱ respiratory failure

作　　者：邓桂胜[1] 罗勇[1] 

机构地区：[1]上海交通大学附属新华医院崇明分院呼吸内科,上海201015

出　　处：《海军医学杂志》2016年第1期30-31,46,共3页Journal of Navy Medicine

摘　　要：目的评价无创正压通气联合纳洛酮治疗慢性阻塞性肺疾病(COPD)急性加重期并发II型呼吸衰竭的疗效。方法治疗组在常规治疗及无创正压通气治疗的基础上加用纳洛酮静脉滴注,对照组在常规治疗的基础上加用无创正压通气,观察2组患者治疗前后血气指标变化及通气时间、住院时间,并进行比较分析。结果治疗组治疗后血气指标优于对照组(P<0.05),机械通气时间治疗组为(5.6±2.0)d,对照组为(7.1±3.0)d,住院时间治疗组为(10.8±2.5)d,对照组为(13.2±3.0)d,2组比较差异均有统计学意义(P<0.05)。结论无创正压通气联合纳洛酮治疗慢性阻塞性肺疾病急性加重期并发II型呼吸衰竭疗效确切,明显缩短机械通气时间及住院时间。Objective To evaluate the curative effect of non-invasive positive pressure ventilation combined with naloxone on acute exacerbation of chronic obstructive pulmonary disease （COPD） complicated with type II respiratory failure. Methods The pa- tients in the treatment group were additionally given naloxone intravenously on the basis of conventional treatment combined with the non-invasive positive pressure ventilation, while the patients in the control group were administered with non-invasive positive pressure ventilation in addition to conventional treatment. Then, changes in blood gas indicators, ventilation time and duration of hospitalization before and after treatment were observed, and analyses were made between the 2 groups. Results After treatment, the blood gas indi- cators of the treatment group were superior to those of the control group （P 〈 0.05 ）. The average ventilation time of the treatment group was （ 5.6 ±2.0） days, while that of the control group was （ 7.1 ± 3.0 ） days ; the length of hospitalization for treatment group was （ 10.8 ± 2.5 ） days and that for the control group was（ 13.2 ± 3.0） days respectively. Statistical significance could be seen, when comparisons were made between the 2 groups （ P 〈 0.05 ）. Conclusion The curative effect of non-invasive positive pressure ventilation plus naloxone was confirmative in the treatment of acute exacerbation of chronic obstructive pulmonary disease complicated with type II respiratory fail- ure, and it could significantly shorten ventilation time and hospital stay.

关 键 词：无创正压通气 纳洛酮 慢性阻塞性肺疾病 呼吸衰竭 

分 类 号：R563[医药卫生—呼吸系统]