维生素D受体基因ApaⅠ、BsmⅠ、Tru9Ⅰ位点多态性与中国人群骨质疏松症关联性的Meta分析  

Apa Ⅰ,Bsm Ⅰ,Tru9 Ⅰ Polymorphisms in Vitamin D Receptor Gene and the Osteoporosis Susceptibility in Chinese Population: a Meta- analysis

作　　者：董佑红[1,2] 艾金伟 李德胜[3] 刘羽[3] 裴斌[1,3] 

机构地区：[1]湖北医药学院附属襄阳医院循证医学中心,湖北襄阳441000 [2]湖北医药学院附属襄阳医院肿瘤科,湖北襄阳441000 [3]湖北医药学院附属襄阳医院整形外科,湖北襄阳441000

出　　处：《湖北医药学院学报》2015年第6期523-531,537,共10页Journal of Hubei University of Medicine

基　　金：湖北省卫计委基金项目(WJ2015MB187)

摘　　要：目的：运用Meta分析的方法探讨维生素D受体（VDR）基因多态性与中国人群骨质疏松症（OP）关联性。方法：计算机检索Pub Med、EMbase、CNKI、CBM、VIP及Wan Fang数据库中有关VDR基因多态性与中国人群OP发病风险的病例—对照研究和队列研究,检索截止日期为2015年10月10日。由2名研究者按纳入和排除标准独立筛选文献、提取数据,采用Rev Man 5.3软件进行统计分析。结果：最终纳入12个病例—对照研究。Meta分析结果显示：VDR基因ApaⅠ位点多态性与OP发病风险有关（AA vs.Aa＋aa：OR=0.38,95%CI=0.19-0.77;AA＋Aa vs.aa：OR=0.44,95%CI=0.29-0.64;AA vs.aa：OR=0.31,95%CI=0.15-0.63;Aa vs.aa：OR=0.48,95%CI=0.31-0.73;A vs.a：OR=0.47,95%CI=0.34-0.64）;VDR基因BsmⅠ位点多态性与OP发病风险无关（BB vs.Bb＋bb：OR=0.66,95%CI=0.12-3.70;BB＋Bb vs.bb：OR=0.90,95%CI=0.63-1.28;BB vs.bb：OR=0.68,95%CI=0.11-4.21;Bb vs.bb：OR=0.95,95%CI=0.66-1.38;B vs.b：OR=0.92,95%CI=0.68-1.23）;VDR基因Tru9Ⅰ位点多态性与OP发病风险有关（TT vs.Tt＋tt：OR=0.39,95%CI=0.17-0.91）。结论：当前的证据显示VDR基因ApaⅠ位点A等位基因及Tru9位点TT基因型可能降低中国人群OP患病风险,而BsmⅠ位点多态性与OP发病风险没有关联性。Objective To investigate the relationship between Vitamin D receptor（ VDR） gene polymorphisms and osteoporosis in chinese population by using Meta-analysis method.Methods Pub Med,EMbase,CNKI,CBM,VIP and Wan Fang databases were searched up to October 10,2015 for relevant publications.Two reviewers selected the studies and extracted information independently.Data extraction form eligible studies were pooled and analyzed by using Rev Man5.3 software.Results Twelve case-control studies were included. The results of meat-analysis showed that the VDR gene Apa Ⅰ and Tru9 Ⅰpolymorphisms associated with the OP risk.Apa Ⅰ with OP： [AA vs. Aa＋aa： OR = 0. 38,95% CI = 0. 19 - 0. 77; AA ＋ Aa vs.aa： OR = 0.44,95%CI = 0.29 - 0.64; AA vs. aa： OR = 0.31,95%CI = 0.15 - 0.63; Aa vs. aa： OR = 0.48,95% CI = 0.31 - 0.73;A vs. a： OR = 0.47,95%CI = 0.34 - 0.64],and Tru9 Ⅰ with OP： [TT vs. Tt＋tt： OR = 0.39,95%CI = 0.17 - 0.91].While,the association between Bsm Ⅰ polymorphism and the risk of OP was not identified[BB vs. Bb＋bb： OR = 0.66,95%CI = 0.12 -3.70; BB＋Bb vs. bb： OR = 0.90,95%CI = 0.63 - 1.28; BB vs. bb： OR = 0.68,95%CI = 0.11 - 4.21; Bb vs. bb： OR = 0.95,95%CI = 0.66 - 1.38; B vs. b： OR = 0.92,95%CI = 0.68 - 1.23].Conclusion Current evidence suggested that the A allele of ApaⅠ and TT genotype of Tru9 Ⅰ may decreased the risk of OP in chinese population.But the Bsm Ⅰ polymorphism may has no associate with the OP susceptibility.

关 键 词：维生素D受体 多态性 骨质疏松症 中国人群 META分析 

分 类 号：R580[医药卫生—内分泌]