2型糖尿病患者血清chemerin水平与骨密度相关性研究  

The relationship between serum chemerin level and bone mineral density in T2DM patients

作　　者：施良[1] 张浩[2] 李林[1] 徐萍[3] 高健青[1] 周建明[1] 毛朝明[1] 

机构地区：[1]江苏大学附属江滨医院核医学科,镇江212001 [2]江苏大学附属江滨医院急诊内科,镇江212001 [3]江苏大学附属江滨医院内分泌科,镇江212001

出　　处：《中国骨质疏松杂志》2016年第1期67-71,共5页Chinese Journal of Osteoporosis

基　　金：国家自然基金资助项目(81370889);镇江市卫生科技重点项目(SH2013075)

摘　　要：目的探讨2型糖尿病患者血清chemerin水平与骨密度及相关因素的关系。方法选取2012年1月~2014年12月本院内分泌科收治的2型糖尿病住院患者,行双能X线骨密度检查,根据WHO骨质疏松诊断标准分为2型糖尿病骨量正常组42例、2型糖尿病骨量减少组50例、2型糖尿病骨质疏松（OP）组58例。记录其身高、体重、病程等临床资料,测定空腹血糖（FBG）、糖化血红蛋白（Hb Alc）、血清chemerin、TNF-α及IL-6水平。另取30名健康人群作为对照组。结果糖尿病患者三组间年龄、身高、体重、病程、糖化血红蛋白无统计学差异。糖尿病骨质疏松组血清chemerin水平高于骨量减少组和骨量正常组（89.7±12.2μg/L;72.5±13.6;65.1±14.9μg/L）,差异均有统计学意义（P〈0.05）。2型糖尿病合并骨质疏松症组血清炎症因子TNF-α和IL-6水平均高于无骨质疏松症组（P〈0.05）。相关性分析结果显示：血清chemerin水平与TNF-α、BMI、Hb A1c、病程相关（r_1=0.52;r_2=0.76;r_3=0.63;r_4=0.59;P均〈0.05）,与腰椎骨密度呈负相关（r=-0.67,P〈0.05）。结论chemerin可能通过调控炎症反应参与骨代谢过程,从而促进骨质疏松的发生。Objective To explore the relationship between serum chemerin level and bone mineral density （BMD） in type 2 diabetic patients. Methods The inpatients with type 2 diabetes were chosen from January 2012 to December 2014 in the Department of Endocrinology of our Hospital. BMD were measured with dual energy X-ray absorptiometry. Patients were divided into type 2 diabetic normal bone mass group （n = 42）, type 2 diabetic osteopenia group （n = 50）, and type 2 diabetic osteoporosis group （n = 58）, according to the WHO diagnostic criteria of osteoporosis. Height, weight, duration of diabetes, and other clinical data were recorded. Fasting blood glucose （FBG） , glycosylated hemoglobin （HbA1c）, serum chemerin, TNF-α, and interleukin- 6 （IL-6） were measured. Another 30 cases of normal people were also included in the study as the control group. Results No significant difference of age and sex, height, weight, duration of diabetes, and HbAlc was found in the type 2 diabetic patients among the three groups. Serum chemerin level in type 2 diabetic osteoporosis group was significantly higher than that in type 2 diabetic osteopenia and normal bone mass group （89.7 ± 12.2 μg/L, 72.5 ± 13.6, and 65. 1 ± 14.9 μg/L, P 〈0.05）. The TNF- α and IL-6 levels in diabetic osteoporosis group were significantly higher than those in type 2 diabetic normal bone mass group （P 〈 0. 05）. Correlation analysis showed that： serum chemerin level was positively correlated with TNF-α, BMI, HbA1c, and duration of diabetes （r1 =0. 52, r2 =0.76, r3 =0. 63, r4 =0. 59, P 〈0.05） , but was negatively correlated with BMD of L1-4 （r = -0. 67, P 〈 0.05 ）. Conclusion Chemerin may be involved in the pathogenesis of diabetic osteoporosis by regulating inflammatory reaction, therefore promotes the occurrence of osteoporosis.

关 键 词：2型糖尿病 CHEMERIN 骨质疏松症 骨密度 

分 类 号：R587.2[医药卫生—内分泌]