病原体逃逸中性粒细胞胞外诱捕网机制  

Mechanism of Pathogen Escape from Neutrophil Extracellular Traps( NETs)

作　　者：夏杰[1] 王蓉[1] 

机构地区：[1]黄冈职业技术学院医药卫生学院,湖北黄冈438000

出　　处：《微生物学杂志》2015年第6期86-89,共4页Journal of Microbiology

摘　　要：中性粒细胞胞外诱捕网(NETs)是新发现的中性粒细胞抗病原机制,是天然免疫系统的重要组成部分。但病原体在进化中形成了针对NETs的免疫逃逸机制。不同的病原体逃逸NET的机制不同,本文主要介绍3种机制:降解NETs-DNA、表面分子机制和NETosis调控。Neutrophil extracellular trap （NET） is a new discovered pathogen-resistant mechanism of neutrophil, it is considered to be the important component of the human innate immunity system. However, during the evolution process the pathogens have formed the mechanism of immune escape against NETs. Different pathogens have different NET escaping mechanisms, such as NETs-DNA degradation, surface molecule and modulation of NETosis were briefly introduced in this paper.

关 键 词：中性粒细胞 中性粒细胞胞外诱捕网 免疫逃逸 病原体 

分 类 号：Q939.91[生物学—微生物学] R392.1[医药卫生—免疫学]