生物活性肽——蛋氨酸脑啡肽的免疫调节作用及其应用前景  

Advances in the Research of the Immunomodulatory effects of Methionine Enkephalin

作　　者：冯鹏辉[1] 单风平[1] 

机构地区：[1]中国医科大学基础医学院免疫学教研室,辽宁沈阳110122

出　　处：《微生物学杂志》2015年第6期100-104,共5页Journal of Microbiology

摘　　要：源自肾上腺前脑啡肽原的具有吗啡样生物活性的内源性神经肽蛋氨酸脑啡肽(methionine enkephalin,MENK),由5个氨基酸残基Tyr-Gly-Gly-Phe-Met组成,与G蛋白偶联的7次跨膜特异性受体结合后发挥不同的生物学功能。目前,对蛋氨酸脑啡肽的作用及其机制研究已经取得了很大进展。本文就MENK对于免疫系统的调节及其对肿瘤、自身免疫病、艾滋病等免疫系统相关疾病的治疗作用予以综述。Preproenkephalin derived from adrenal gland possessed bioactivity of morphine-like substance oi endoge- nous neuropeptide methionine enkephalin （MENK） , is composed of five amino acid residues Tyr-Gly-Gly-Pbe-Met. It brought into play of different bio-functions after coupled with seven-transmembrane specific domain G-protein-coupled receptor. At present, much progress has been made in the research of the modulatory effect and mechanism of methio- nine enkephalin. The regulation on immune system of MENK and the therapy effects of antitumor, autoimmune disea- ses, AIDS, and other immune-related diseases were summarized in this paper.

关 键 词：蛋氨酸脑啡肽 阿片生长因子 阿片肽 阿片生长因子受体 免疫调节 

分 类 号：Q939.93[生物学—微生物学] R392.6[医药卫生—免疫学]