尼古丁受体基因rs1051730多态性与慢性阻塞性肺疾病的Meta分析  

Correlation between rs1051730 polymorphism in nicotinic acetylcholine receptors with COPD:a meta-analysis

作　　者：李明一 梁爽[1] 王靖思[1] 崔凯[1] 

机构地区：[1]辽宁医学院公共卫生学院,辽宁锦州121001

出　　处：《现代预防医学》2016年第4期580-583,共4页Modern Preventive Medicine

基　　金：辽宁省大学生创新创业训练计划项目(201410160050)

摘　　要：目的探讨尼古丁乙酰胆碱受体α3亚基（α-3 nicotinic acetylcholine receptor,CHRNA3）基因rs1051730位点多态性与慢性阻塞性肺疾病（Chronic Obstructive Pulmonary Disease,COPD）发病风险的关系。方法检索Pub Med、CNKI等中、英文数据库,收集有关rs1051730位点多态性与COPD关联性的病例对照研究,提取相关数据进行Meta分析,计算OR值及其95%置信区间（95%Confidence Intervals,95%CI）,根据研究对象种族进行亚组分析。结果共有7篇文献纳入本研究,累计病例数5259名,对照组11 913名。Meta分析结果显示,在显性遗传模型（CT＋TT vs CC）条件下,rs1051730与COPD发病风险相关（OR=1.22,95%CI=1.12～1.32,P〈0.001）;亚组分析结果显示,该关联性仅存在于欧洲人种中（OR=1.11,95%CI=1.12～1.32,P〈0.001）,而在中国汉族人群中,rs1051730与COPD无关联（OR=1.23,95%CI=0.90～1.67,P=0.191）。等位基因模型（T vs C）和隐性模型（TT vs CT＋CC）条件下均得出类似结论。结论 CHRNA3基因rs1051730位点多态性与欧洲人群COPD发病相关,携带T等位基因能够显著增加COPD的发病风险。Objective This work was to explore the correlation between the polymorphism of rs1051730 in an CHRNA3 subunit （α-3 nicotinic acetyleholine receptor） with chronic obstructive pulmonary disease （COPD）. Methods A comprehensive literature research was conducted to find studies reporting correlation between rs1051730 and COPD. ORs （Pooled odds ratios） with 95% CIs （95% confidence intervals） were calculated. Subgroup analyses were conducted according to the ethnicity of the study population. Results A total of 7 articles with 5259 cases and 11913 controls were included in this analysis. Under dominant model （CT＋TT vs CC）, significant correlation between rs1051730 and COPD were identified （OR=1.22, 95% CI=1.12-1.32, P〈0.001）. However, this correlation only existed among European （OR=1.11, 95% CI=1.12-1.32, P〈0.001）, not Chinese （OR=1.23, 95% CI=0.90-1.67, P=0.191）. The similar results were found by both allele model （T vs C） and recessive model （TT vs CT＋CC）. Condusion Rs1051730 in CHRNA3 was associated with COPD among European, and the T allele could increase the COPD risk.

关 键 词：尼古丁乙酰胆碱受体 COPD 多态性 META分析 

分 类 号：R181.2[医药卫生—流行病学]