橙皮素胶束溶液的制备及透明质酸对其稳定性和经皮渗透作用的影响  

Preparation of hesperetin micelle pseudo solution and influence of hyaluronic acid on its stability and percutaneous osmosis action

作　　者：张晓宇[1] 侯彩平[1] 赵丽萍[2] 谢茵[1] 刘丽清[2] 何亚丽[2] 田青平[1] 

机构地区：[1]山西医科大学药学院,山西太原030001 [2]太原市第二人民医院药剂科,山西太原030001

出　　处：《日用化学工业》2016年第2期92-96,共5页China Surfactant Detergent & Cosmetics

基　　金：山西省科技攻关项目(20140313018-8)

摘　　要：制备橙皮素胶束溶液,并以Zeta电位和经皮渗透速率为指标,考察透明质酸对胶束溶液稳定性和经皮渗透活性的影响。结果表明,透明质酸可显著提高橙皮素胶束溶液的稳定性和经皮渗透活性,当其质量分数为0.5%时,胶束溶液透明稳定、无不良气味,室温下pH平均值为5.4±0.1,Zeta电位平均值为-32.62 m V,橙皮素经豚鼠皮肤的稳态渗透速率常数Js达7.475 8μg/(cm^2·h),为对照组的1.5倍。橙皮素胶束溶液耐寒和耐热实验均表现出良好的稳定性。Pseudo solution of hesperetin micelle was prepared,and influence of hyaluronic acid on its stability and percutaneous osmosis activity was investigated using Zeta potential and percutaneous osmosis rate as the respective indices. Experimental results showed that hyaluronic acid can significantly enhance the stability and percutaneous osmosis activity of hesperetin micelle pseudo solution. When the mass fraction of hyaluronic acid achieves 0. 5%,the micelle pseudo solution becomes transparent,stable and without unpleasant odor. Under room temperature condition,its average p H value is 5. 4 ± 0. 1 and average Zeta potential is- 32. 62 m V. The steady osmosis rate constant Jsof hesperetin through cavy skin achieves 7. 475 8 μg /（ cm2·h）,which is1. 5 multiples as compared with that of the control group. The micelle pseudo solution shows good stability in cold resistance test and heat resistance test.

关 键 词：护肤化妆品添加剂 橙皮素 胶束 透明质酸 稳定性 经皮渗透活性 

分 类 号：TQ658[化学工程—精细化工]