血液灌流治疗急性重度有机磷中毒的临床研究  

Hemoperfusion for Acute Severe Organophosphorus Poisoning

作　　者：唐斌[1] 傅强[1] 王东旺[1] 陈运和[1] 陈宁南[1] 黄丹[2] 

机构地区：[1]江西省人民医院急诊科 [2]南昌大学第二附属医院麻醉科,南昌330006

出　　处：《实用临床医学（江西）》2015年第12期7-9,共3页Practical Clinical Medicine

摘　　要：目的评价血液灌流(HP)对重度急性有机磷农药中毒(AOPP)的临床疗效。方法对60例重度AOPP患者回顾性分析。按治疗方法的不同,分为HP组和单纯药物组。单纯药物组(n=30)按常规洗胃、阿托品、复能剂、及时予以人工呼吸支持、防治肺水肿和脑水肿治疗;HP组(n=30)在综合治疗的基础上加用HP。比较2组临床疗效。结果 HP组较单纯药物组,昏迷时间、住院时间、入院24h后血CHE水平、呼吸机使用时间、CHE恢复至50%的时间、阿托品总用量明显减少,而治愈率明显提高(P<0.05)。HP组不良反应轻微。结论对重度AOPP患者在综合治疗基础上加用HP,能更好地帮助患者平稳渡过危险期,使患者获益。Objective To evaluate the clinical efficacy of hemoperfusion（HP） in the treatment of acute severe organophosphorus poisoning（AOPP）. Methods Data of 60 patients with AOPP were analyzed retrospectively. These patients were divided into drug treatment group（nz30） and H P treatment group（n： 30）. All patients were given routine gastric lavage, atropine, cholinesterase（CHE） resurrection agent, artificial respiratory support, and treatment for lung edema and brain edema. In addition, patients in HP treatment group were treated with HP. Clinical efficacy was compared between the two groups. Results Compared with drug treatment group, HP treatment significantly reduced the coma duration, hospital stay, 24-hour blood cholinesterase levels, mechanical ventilation time, time to CHE restoration to 50% and total amount of atropine, and markedly increased the cure rate（P〈0.05）. Only mild adverse reactions occurred in HP treatment group. Conclusion HP treatment can help patients smoothly live through the dangerous period based on comprehensive treatment for AOPP.

关 键 词：血液灌流 急性有机磷农药中毒 重度 

分 类 号：R595.4[医药卫生—内科学]