脂蛋白磷脂酶A2在2型糖尿病及其大血管病变中的作用  

The value of lipoprotein-associated phospholipase A2 in type 2 diabetes mellitus and the macrovascular complications

作　　者：苏敏[1] 薛莉[1] 

机构地区：[1]江苏省南通市中医院内分泌科,226001

出　　处：《中国现代医药杂志》2015年第10期55-57,共3页Modern Medicine Journal of China

摘　　要：目的探究脂蛋白磷脂酶A2在2型糖尿病大血管病变中的作用。方法选择26例2型糖尿病合并颈动脉粥样斑块患者和24例单纯2型糖尿病患者,分别测定脂蛋白磷脂酶A2水平,并对结果进行组间比较。结果 2型糖尿病合并颈动脉粥样斑块组脂蛋白磷脂酶A2水平高于单纯2型糖尿病患者,且低密度脂蛋白、糖化血红蛋白、颈动脉内中膜厚度水平均高于单纯2型糖尿病患者,组间比较差异存在统计学意义(P<0.05)。结论脂蛋白磷脂酶A2对2型糖尿病患者早期大血管病变有预测作用,为糖尿病大血管病变的早期干预提供了帮助。Objective To investigate the relation between the level of lipoprotein-associated phospholipase A2 （Lp- PLA2） with type 2 diabetes mellitus and its vascular complications. Methods Collected the clinical data of 26 patients with type 2 diabetes mellitus complicated with carotid atherosclerotic plaque and 24 cases of type 2 diabetes mellitus without vascu- lopathy .The lipoprotein-associated phospholipase A2 levels were measured respectively, and carried on the comparison between two groups. Results The lipoprotein-associated phospholipase A2 level was significantly higher in patients with type 2 dia- betes mellitus complicated with carotid atherosclerotic plaque than that in patients with type 2 diabetes mellitus without macrovasculopathy. Meanwhile, the levels of low density lipoprotein cholesterol （HDL-c）, glycosylated hemoglobin and carotid intima-media thickness in patients with type 2 diabetes mellitus complicated with carotid atherosclerotic plaque were also higher than that in patients with type 2 diabetes mellitus without macrovasculopathy. There was significant difference between two groups （P〈0.05）. Conclusion The lipoprotein-associated phospholipase A2 has the predictional significance for early maerovasculopathy in type 2 diabetes mellitus, and is helpful for early intervene of diabetic macrovaseulopathy in type 2 diabetes mellitus.

关 键 词：脂蛋白磷脂酶A2 2型糖尿病 大血管病变 

分 类 号：R587.2[医药卫生—内分泌]