坦索罗辛治疗输尿管上中段结石的疗效观察  

Effect of tamsulosin on stone expulsion in proximal and medial ureteral calculi

作　　者：柳宏林[1] 陈杲[1] 莫宏辉[1] 肖智彬[1] 叶超平[1] 尹三省[1] 覃宝笋[1] 

机构地区：[1]广西壮族自治区南溪山医院泌尿外科,广西桂林541002

出　　处：《中国现代医药杂志》2015年第11期14-16,共3页Modern Medicine Journal of China

基　　金：广西壮族自治区卫生厅自筹经费科研课题基金资助项目(编号:Z2013288)

摘　　要：目的评价坦索罗辛治疗输尿管上、中段结石的疗效。方法 118例输尿管结石患者随机分成两组,实验组62例患者服用坦索罗辛0.4mg,1次/d,尿石通丸4g,2次/d。对照组56例患者服用尿石通丸4g,2次/d,肾绞痛发作时根据需要每次肌注盐酸哌替啶注射液50~100mg。随访8周评估两组结石排出率、排出时间,镇痛药的使用率及药物副作用。结果8周内实验组输尿管上、中段排石率分别为66.67%、71.43%,对照组输尿管上、中段结石排除率分别为40.91%、25.00%,两组比较差异有统计学意义（P〈0.05）;实验组输尿管上、中段结石排出时间分别为（21.53±7.14）d、（10.00±5.54）d,对照组输尿管上、中段结石排石时间分别为（29.86±6.36）d、（15.00±4.08）d,两组比较差异有统计学意义（P〈0.05）。两组患者中因肾绞痛发作不能耐受疼痛而需给予盐酸哌替啶注射液进行干预,实验组上、中段结石患者所占比例分别为16.67%、14.29%,对照组上、中段结石患者所占比例分别为54.55%、58.33%,两组比较差异有统计学意义（P〈0.05）。实验组1例患者服用坦索罗辛后发生轻微头晕,因症状较轻未予对症处理,副作用发生率为1.61%。结论盐酸坦索罗辛能提高输尿管上、中段结石的排出率,缩短结石排出时间,减少镇痛。Objective To evaluate the efficacy Methods A total of 118 patients with the ureteral stones of tamsulosin for proximal and medial ureteral calculi expulsion. （4~10mm in diameter） were randomly divided into two groups. The experimental group accepted Niaoshitong pill （4g,Bid） and tamsulosin （0.4mg,Qd）, and the control group only accepted Niaoshitong pill （4g, Bid）. All patients were followed up for 8 weeks. The stone expulsion rate, stone expulsion time, usage rate of analgesic and side effect of medication were observed in both groups. Results The stone expulsion rate of proximal and medial ureteral calculi was 66.67%, 71.43% respectively in experimental group, and in control group was 40.91%, 25.0% re- spectively. The average expulsion time for proximal ureteral stones patients, medial ureteral stones patients of the experimental group was （21.53±7.14）d, （10.00±5.54）d, and in the control group was （29.86±6.36）d, （15.00±4.08）d, respecivly. For prox- imal ureteral stones patients, medial ureteral stones patients in the experimental group analgesic administer rate was 16.67%, 14.29%, and in the control group was 54.55% ,58.33% ,respectively. In the experimental group adverse effect rate was 1.61%, and in the control group was 0,respectively. A significant difference was observed in the stone expulsion rate, stone expulsion time and usage rate of analgesic between the two groups. Conclusion It is demonstrated that tamsulosin is safe and effective for the management of proximal ureteral stones, it can significantly increase the stone expulsion rate, shorten expulsion time and reduce the need for analgesics.

关 键 词：Α1受体阻滞剂 盐酸坦索罗辛 输尿管结石 

分 类 号：R693.4[医药卫生—泌尿科学]