鲜鱼腥草多糖与总黄酮抗辐射作用机制的对比  

Contrast of Fresh Cordate Houttuynia Polysaccharides and Flavones Radiation Mechanism

作　　者：王洪生[1] 洪佳璇[1] 冯丙江 孙东海[1] 蒋婧瑾[2] 

机构地区：[1]杭州市萧山区中医院,浙江杭州311201 [2]浙江大学医学院,浙江杭州310009

出　　处：《绍兴文理学院学报》2015年第10期29-32,共4页Journal of Shaoxing University

基　　金：萧山科技计划项目(2012439)

摘　　要：目的探讨鲜鱼腥草叶提取物对X射线辐射损伤大鼠骨髓造血功能和免疫功能的影响.方法将造模成功的24只大鼠随机分为3个组,分别为模型对照组(模型组)、总黄酮组、多糖组,每组各8只,分别给予等体积的蒸馏水、总黄酮提取液(5.23g/kg)、和多糖粉末混悬液(2g/kg)灌胃.结果鲜鱼腥草多糖与总黄酮皆能够对受X射线辐射损伤的大鼠起到保护和治疗的作用;鱼腥草总黄酮成分可显著增加白细胞数,升高脾脏指数,增加骨髓DNA含量,降低外周血网织红细胞微核率和骨髓嗜多染红细胞微核率,可增加SOD及GSH-Px的含量;鱼腥草多糖可显著升高大鼠胸腺指数和脾脏指数,明显降低外周血和骨髓微核率,显著提高SOD、CAT和GSH-Px含量.结论鲜鱼腥草叶具有较好的抗辐射作用,其提取物的作用机制和作用的有效部位有所不同.Objective ： To investigate the effects of Houttuynia cordata leaf extract damage of bone marrow hematopoietic function and immune function in rats of X ray radiation. Methods ： The rest of the successful model of 24 rats were randomly divided into 3 groups： model control group （model group）, total flavone group and polysaccharide group, each having 8 rats. SLN were poured into the stomach volume of distilled water, total flavonoids extract 5.23g/kg and polysaccharide powder suspension （2g/kg） gavage. Results： Fresh Houttuynia polysaccharide and total flavonoids can have a protective and therapeutic effect on rats injured by x-rays. Houttuynia corda- ta flavonoids can significantly increase the number of white cells, the spleen index and the content of bone marrow DNA, with the micronucleus rate of red blood cell and the Micronucleus Rate of Bone Marrow Polychromatic Erythrocyte of rats decreased; it can increase the content of SOD and GSH-Px. Polysaccharide of Houttuynia cordata could remarkably increase the thymus index and spleen index of rats and the content of SOD, CAT and GSH-Px; it could significantly lower the peripheral blood and bone marrow micronucleus rate. Conclusion： Houttuynia cordata Thunb fresh leaves have a good anti-radiation effect with a different effect mechanism and diversified effective parts of the body

关 键 词：鲜品鱼腥草叶 大鼠 辐射损伤 抗辐射 

分 类 号：R818.05[医药卫生—放射医学]