右美托咪定联合美维松在小儿扁桃体摘除手术中的应用  

Combined Application of Dexmedetomidine with Mivacurium in Pediatric Tonsillectomy

作　　者：李阳[1] 万玉骁 杨延超[1] 滕秀飞 李真[1] 朱俊超[1] 

机构地区：[1]中国医科大学附属盛京医院麻醉科,沈阳110004

出　　处：《中国医科大学学报》2016年第3期260-263,共4页Journal of China Medical University

摘　　要：目的探讨小儿扁桃体摘除手术麻醉中术前预注右美托咪定对美维松起效时间和维持时间的影响。方法选取择期全麻下行扁桃体摘除手术患儿40例,随机分为对照组和右美托咪定组,每组20例。右美托咪定组于麻醉前15 min静脉泵注右美托咪定(1.0μg/kg),对照组同法静脉泵注等量0.9%氯化钠注射液。采用TOF刺激方式监测拇内收肌的收缩反应,记录美维松的起效时间和维持时间。结果与对照组相比,右美托咪定组美维松的起效时间缩短(P<0.05),维持时间无明显影响(P>0.05)。结论术前预注右美托咪定可缩短美维松的起效时间,对维持时间无影响,无肌松药残余风险,在小儿扁桃体摘除手术麻醉中联合应用右美托咪定与美维松安全有效。Objective To investigate the effects of dexmedetomidine on the onset time and clinical duration of mivacurium in pediatric tonsillectonay. Methods Forty patients undergoing pediatric tonsillectomy during general anesthesia were recruited for the study and randomly divided into dexmedetomidine group （ group D ） and control group （ group C ） with 20 cases in each. In group D, a bolus dose of 1.0 μg / kg of dexmedetomidine was infused in 15 minutes before anesthesia induction. Normal saline was administrated in the same way in group C. MAP and HR were recorled before infused, after infused and before induction. The onset time and clinical duration were also recorded. Results The onset time of mivacuritan in dexmedetomidine group （group D） was shorten （ P 〈 0.05 ） and there was no significant effects on the clinical duration （P 〉 0.05 ）. Conclusion Dexmedetomidine administration before general anesthesia can shorten the onset time but do not lengthen the clinical duration of mivacurium, and there＇ s no risk on the residual of mivacurium. The combined use of the two drugs can be safely applied in pediatric tonsillectomy.

关 键 词：右美托咪定 美维松 起效时间 维持时间 

分 类 号：R614.2[医药卫生—麻醉学]