异甘草酸镁注射液与注射用还原型谷胱甘肽配伍的稳定性分析  

Compatible stability of magnesium isoglycyrrhizinate injection and reduced glutathione for injection

作　　者：李晓晖[1] 文娱[2] 晋文慧[3] 洪专[3] 曾美燕[2] 陈伟珠[3] 

机构地区：[1]厦门市中医院药物临床试验机构,福建厦门361009 [2]厦门市中医院药剂科,福建厦门361009 [3]国家海洋局第三海洋研究所,福建厦门361005

出　　处：《临床肝胆病杂志》2016年第1期143-147,共5页Journal of Clinical Hepatology

基　　金：福建中医药大学2014年校管课题(XB2014050)

摘　　要：目的考察异甘草酸镁(MgIG)注射液与注射用还原型谷胱甘肽(GSH)在室温条件下配伍的稳定性。方法采用高效液相色谱法测定MgIG注射液与注射用GSH在5%、10%葡萄糖溶液中配伍的浓度变化。结果 MgIG注射液与注射用GSH配伍液在0、0.5、1、1.5、2、4 h内浓度均无明显变化。结论 MgIG注射液与注射用GSH在5%、10%葡萄糖溶液中可以配伍使用,但应在4 h内用完。Objective To evaluate the compatible stability of magnesium isoglycyrrhizinate （MgIG） injection and reduced glutathione （GSH） for injection at room temperature. Methods High -performance liquid chromatography was applied to measure the changes in the content of MgIG and reduced GSH after MgIG injection and reduced GSH for injection were mixed with 5% or 10% glucose solution. Resuits There were no significant changes in the content of MgIG and reduced GSH within 0, 0.5, 1, 1.5, 2, and 4 h after MgIG injection and reduced GSH for injection were mixed with 5% or 10% glucose solution. Conclusion MgIG injection and reduced GSH for injection are compatible in 5% and 10% glucose solutions, but the mixed solution should be used within 4 h.

关 键 词：异甘草酸镁 谷胱甘肽 中药配伍 药物稳定性 

分 类 号：R969.2[医药卫生—药理学]