HBV感染小鼠模型的研究进展  

Research advances in mouse models of hepatitis B virus infection

作　　者：王军[1] 黄豫晓[1] 沈燕[1] 梁姣[1] 刘学武[1] 李英辉[1] 赵亚[1] 

机构地区：[1]第四军医大学基础部,病原生物学教研室,西安710032

出　　处：《临床肝胆病杂志》2016年第1期165-168,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金(31172167)

摘　　要：HBV由于其较强的种属特异性,目前尚缺乏理想的实验动物模型来阐明其具体的发病机制。目前有关HBV感染模型的研究大多集中在小鼠方面,并已取得了很大进展。综述了HBV转基因小鼠、HBV转染小鼠和人鼠嵌合肝脏HBV小鼠等模型的优缺点,提出合理使用这些模型有助于更好地阐明HBV的致病机制。Hepatitis B virus （HBV） is a great threat to human health, but due to its strong species specificity, there are still no ideal animal models at present to clarify the pathogenesis of HBV infection. At present, the research on HBV infection models mainly concentrates on mice, and great progress has been achieved/made. This review focuses on the advantages and disadvantages of HBV transgenic mouse mod- el, HBV - transfected mouse model, and human - mouse chimeric liver HBV mouse model, and suggests that rational application of these models helps to clarify the pathogenesis of HBV.

关 键 词：肝炎病毒 乙型 模型 动物 小鼠 转基因 综述 

分 类 号：R512.62[医药卫生—内科学]