血清特异性抗体测定在婴幼儿特应性皮炎致敏原检测中的意义  

Significance of serum specific antibodies determination in allergens detection of infantile atopic dermatitis

作　　者：韦祝[1] 刘向宇[1] 罗勇奇[1] 何谢玲[1] 汤建萍[1] 

机构地区：[1]湖南省儿童医院皮肤科,湖南长沙410007

出　　处：《中国妇幼保健》2016年第5期996-998,共3页Maternal and Child Health Care of China

基　　金：国家自然基金(81301381)

摘　　要：目的探讨血清特异性抗体测定在婴幼儿特应性皮炎致敏原检测中的意义,为临床婴幼儿特应性皮炎的诊治提供依据。方法选择2012-2014年湖南省儿童医院皮肤婴幼儿特应性皮炎80例作为特应性皮炎组,健康婴幼儿80例作为对照组。采用酶联免疫法测定血清中过敏原的IgG抗体和Ig E抗体情况。结果特应性皮炎组患者外源性过敏原IgG抗体检测阳性率比较高的有牛奶、鸡蛋和虾。特应性皮炎组患者鱼和虾特异性IgE抗体检测阳性率明显高于特异性IgG抗体检测阳性率(P<0.05);特应性皮炎组患者牛奶、鸡蛋、大豆、小麦和猪肉特异性Ig E抗体检测阳性率与特异性IgG抗体检测阳性率之间没有明显差异(P>0.05)。特应性皮炎组患者牛奶、鸡蛋特异性IgG抗体检测阳性率明显高于对照组(P<0.05);特应性皮炎组患者大豆、鱼、虾、小麦和猪肉特异性IgG抗体检测阳性率与对照组之间比较没有明显差异(P>0.05)。特应性皮炎组患者鸡蛋、牛奶、户尘螨、粉尘螨、虾特异性IgE抗体检测阳性率明显高于对照组(P<0.05);特应性皮炎组患者大豆、鱼、小麦和猪肉特异性IgE抗体检测阳性率与对照组之间比较没有明显差异(P>0.05)。结论 IgE抗体和IgG抗体的检测快速方便,能够有效地检测到特应性皮炎组的过敏原,在婴幼儿特应性皮炎的诊断和治疗中具有重要意义。Objective To explore the significance of serum specific antibodies determination in allergen detection of infantile atopie dermatitis, provide a basis for clinical diagnosis and treatment of infantile atopie dermatitis. Methods Eighty infants with atopic dermatitis were selected from the hospital from 2012 to 2014 as atopic dermatitis group, eighty healthy infants were selected as control group. ELISA was used to detect IgG antibodies and IgE antibodies of serum antigens. Results In atopic dermatitis grouP, the positive rates of IgG anti- bodies of mild, eggs, and shrimp were relatively high among exogenous allergens; the positive rates of specific lgE antibodies of fish and shrimp were statistically significantly higher than those of specific lgG antibodies （P〈0. 05） ; there was no statistically significant difference between positive rates of specific IgE antibodies and positive rates of specific IgG antibodies of milk, eggs, soy, wheat, and pork （P〉 0. 05 ） . The positive rates of specific IgG antibodies of milk and eggs in atopic dermatitis group were statistically significantly higher than those in control group （ P〈0.05 ） ; there was no statistically significant difference in the positive rates of specific IgG antibodies of soy, fish, shrimp, wheat, and pork between atopic dermatitis group and control group （P〉0.05） . The positive rates of specific IgE antibodies of eggs, milk, Dermatophagoides pteronyssinus, Dermatophagoides culinae, and shrimp in atopic dermatitis group were statistically significantly higher than those in control group （ P〈0. 05 ） ; there was no statistically significant difference in the positive rates of specific IgE antibodies of soy, fish, wheat, and pork between atopic dermatitis group and control group （P〉0. 05） . Conclusion IgE antibodies and IgG antibodies detection are quick and convenient, which can effectively detect allergens of infantile atopic dermatitis, the method is important in diagnosis and treatment of infantile atopic dermatitis.

关 键 词：婴幼儿 特应性皮炎 IGE抗体 IGG抗体 

分 类 号：R751[医药卫生—皮肤病学与性病学]