响应曲面法优化mal-PEG-PCL载药纳米粒子的制备工艺  

Optimization and reparation of mal-PEG-PCL drug-loading nanoparticles by the response surface methodology

作　　者：尤静[1] 余丽丽[1] 康妮[1] 李娇娇[1] 

机构地区：[1]西安医学院药学院,西安710021

出　　处：《化工新型材料》2016年第2期204-206,共3页New Chemical Materials

基　　金：国家自然科学基金青年基金(81302706);陕西省教育厅科研计划项目(2013JK0759);国家级大学生创新创业训练计划项目(201411840018)

摘　　要：利用开环聚合反应合成聚合物马来酰亚胺-聚乙二醇-聚己内酯(mal-PEG-PCL),并以其为载体,盐酸多柔比星(DOX)为模型药物,利用响应曲面法分析探讨了载体对DOX在不同条件下的包载能力。响应曲面法得到的优化工艺为:DOX投量3mg,三乙醇胺80μL,缓冲液pH为8,预期载药量15%,实验值为14.86%。结果说明:合成的聚合物载体mal-PEG-PCL对模型药物具有较好的包载能力,粒径达到了纳米级且分散度良好。The polymer maleimide-polyethylene glycol-polycaprolactone （mal-PEG-PCL） was synthesized by ring opening polymerization. The obtained amphiphilic polymer was studied as drug carrier using doxorubicin hydrochloride （DOX） as a model drug. Moreover, the drug package load capacity under different conditions was optimized using the re sponse surface method. The optimization of the process was：DOX 3mg, triethanolamine 80μL, pH 8. The expected drug loadings and the experimental value were 15% and 14.86% respectively. The results showed that the obtained mal-PEGPCL had good load capacity to model drug,and the particle size was nanoscale with a good dispersion.

关 键 词：mal-PEG-PCL 响应曲面法 纳米 制备 

分 类 号：TB383.1[一般工业技术—材料科学与工程] TQ460.1[化学工程—制药化工]