细菌性阴道炎对阴道免疫环境的影响  

Effect of Bacterial Vaginitis on the Immune Environment of Vagina

作　　者：姚锋[1] 

机构地区：[1]南通大学附属医院妇产科,江苏南通226001

出　　处：《中外医疗》2015年第34期80-82,共3页China & Foreign Medical Treatment

摘　　要：目的探讨细菌性阴道炎对阴道内免疫环境的影响。方法 2015年1—7月整群收集该院诊治的80例细菌性阴道炎患者和80例正常妇女阴道灌洗液和白带,ELISA检测阴道灌洗液中IL-1β,IL-6,IL-8及HBD-2。白带涂片革兰氏染色镜检阴道杆菌和其他杂菌的数目。结果细菌性阴道炎组较正常妇女组阴道内IL-1β水平升高(P<0.001),HBD-2水平降低(P<0.001),IL-6,IL-8差异无统计学意义(P=0.631,P=0.764)。细菌性阴道炎组较正常妇女组阴道内杂菌数量增多(P<0.001),阴道杆菌数量减少(P<0.001)。结论阴道杆菌对阴道内环境有免疫调节作用,细菌性阴道炎杂菌生长会破坏阴道内免疫环境。Objective To study the effect of bacterial vaginitis on the immune environment of vagina. Methods From Jan-uary 2015 to July 2015 ,vaginal lavage fluid and leucorrhea of 80 cases of bacterial vaginitis patients and 80 cases of nor-mal women were collected , IL-1β,IL-6, IL-8 and HBD-2 in vaginal lavage fluid were detected by ELISA, the number of vagina bacillus and other miscellaneous bacteria was examined by leucorrhea smear gram staining microscopic. Results Compared with the normal women group, IL-1βlevel of vaginal internal in the bacterial vaginitis group increased （P〈0.001） and HBD-2 decreased （P〈0.001）,the difference of IL-6 and IL-8 was not statistically significant （P=0.631,P=0.764）. Compared with the normal women group, the number of miscellaneous bacteria in the bacterial vaginitis group increased （P〈0.001）but the number of vagina bacillus decreased （P〈0.001）. Conclusion Vagina bacillus has an immune and adjustment effect on vaginal internal environment and the growth of bacterial vaginitis bacteria can destroy vaginal internal immune environment.

关 键 词：细菌性阴道炎 阴道杆菌 免疫环境 细胞因子 

分 类 号：R711.31[医药卫生—妇产科学]