放化综合治疗在乳腺癌脑转移的临床疗效评价  

Evaluation of the Clinical Efficacy of Chemoradiotherapy in the Treatment of Breast Cancer with Brain Metastases

作　　者：姜丽娜[1] 李江涛[1] 刘薇[1] 

机构地区：[1]郑州人民医院乳腺外科,河南郑州450003

出　　处：《中外医疗》2015年第33期4-5,共2页China & Foreign Medical Treatment

摘　　要：目的探究放化综合治疗在乳腺癌脑转移的临床疗效。方法整群选取2008年6月—2015年7月该院放疗科乳腺癌脑转移住院患者84例进行回顾性研究,将其按治疗方法不同分为研究组和对照组各42例。对照组进行单纯放疗,研究组在此基础上予以卡培他滨联合治疗。记录两组患者的临床疗效和各不良反应。结果治疗后,研究组患者的总有效率(80.9%)明显高于对照组(64.29%),两组比较差异有统计学意义(P<0.05)。研究组患者恶心、呕吐、白细胞下降等并发症发生率为与对照组比较,差异均无统计学意义(P>0.05)。结论放化综合治疗在乳腺癌脑转移的临床应用中安全、有效,适合临床上推广应用。Objective To evaluate the clinical efficacy of chemoradiotherapy in the treatment of breast cancer with brain metastases. Methods 84 cases with breast cancer and brain metastases underwent hospitalization in Department of Radio-therapy of our hospital from June 2008 to July 2015 were selected for the study and randomly divided into the study group and the control group with 42 cases in each. Both groups were given radiotherapy, in addition, the study group were given capecitabine for treatment. And the clinical efficacy and incidence of adverse reactions of the two groups were recorded. Results After treatment, the study group had higher total efficiency than the control group （80.9% vs 64.29%） with statisti-cally significant difference （P〈0.05）. The differences in the incidence of nausea, vomiting, leucopenia and other complica-tions between the two groups were not statistically significant （P〉0.05）. Conclusion Chemoradiotherapy is safe and effective for the treatment of breast cancer with brain metastases, it is suitable for clinical application and promotion.

关 键 词：放化综合治疗 乳腺癌 脑转移 

分 类 号：R5[医药卫生—内科学]