沙利度胺联合右佐匹克隆片和抗组胺药物治疗顽固结节性痒疹30例临床观察  

The Theraputic Evaluation of Thalidomide Joint Eszopiclone Tablets and Antihistamine in 30 Patients with Serious Prurigo Nodularis

作　　者：黎昌强 廖勇梅 许飏 熊霞 何渊民 

机构地区：[1]四川医科大学附属第一医院,四川泸州646000

出　　处：《中国皮肤性病学杂志》2016年第3期261-262,277,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的评价沙利度胺联合右佐匹克隆片及抗组胺药物治疗顽固结节性痒疹的疗效及安全性。方法将入选的60例顽固结节性痒疹患者按就诊顺序随机分为两组,各30例。全部患者予沙利度胺50mg口服,2次/d,并每天晨予盐酸西替利嗪10mg和每晚予富马酸酮替芬1mg口服,治疗1个月后停用盐酸西替利嗪,沙利度胺50mg改为每晚口服1次,继续治疗2个月。治疗组同时每晚予右佐匹克隆片3mg口服,治疗1个月后改为隔天晚上1次3mg口服,继续治疗2个月。结果治疗3个月时,两组患者睡眠质量评分差异有统计学意义(P<0.05),治疗组有效率96.67%,对照组有效率86.67%,差异无统计学意义(P>0.05),仅痊愈率(83.33%和56.67%)差异有统计学意义(P<0.05)。结论沙利度胺联合右佐匹克隆片及抗组胺药物治疗顽固结节性痒疹可提高患者睡眠质量,有利于患者恢复,并提高治愈率。Objective To observe the effects and security of thalidomide joint eszopiclone tablets and antihistamine in patients with serious prurigo nodularis. Methods According to treatment sequence the selected 60 patients were randomly divided into two groups. All patients were treated with thalidomide 50 mg,2 times / d,and then cetirizine hydrochloride 10 mg qd and ketotifen 1mg qn. After 1 month treatment the dose of thalidomide was adjusted to 50 mg qn and ketotifen 1mg qn for two months. To the observation group,except the methods of above,another drug eszopiclone tablets was chosen,in the first month,with eszopiclone tablets 3mg qn,and next 2 month with eszopiclone tablets 3mg qon. Results After 3 months treatment,the differences of the sleep quality scores between observation group and control group was statistically significant. The cure rate of observation group was 83. 33%,efficiency was 96. 67%; the cure rate of control group was 56. 67%,efficiency was 86. 67%. The two groups of efficiency difference was no statistically significant（ P〉0. 05）,but the cure rate（83. 33% and 56. 67%） difference was statistically significant（ P〈 0. 05）. Conclusion Thalidomide joint eszopiclone tablets and antihistamine treatment of patients with serious prurigo nodularis improve sleep quality,promote patient recovery and improve the cure rate.

关 键 词：沙利度胺 右佐匹克隆片 结节性痒疹 治疗 

分 类 号：R758.3[医药卫生—皮肤病学与性病学]