天然来源α-葡萄糖苷酶抑制剂筛选方法的研究进展  

Review on Screening Methods for alpha-Glucosidase Inhibitors from Natural Resources

作　　者：范莉[1,2] 王业玲[1] 唐丽[1] 

机构地区：[1]中央民族大学生命与环境科学学院,北京100081 [2]华中科技大学同济医学院附属同济医院药学部,武汉430030

出　　处：《天然产物研究与开发》2016年第2期313-321,306,共10页Natural Product Research and Development

基　　金：教育部新世纪优秀人才支持计划(NCET-12-0578);高等学校学科创新引智计划(B08044);国家大学生创新创业训练项目(GCCX2013110019)

摘　　要：α-葡萄糖苷酶抑制剂(alpha-glucosidase inhibitors,AGI)是一类通过延缓肠道内碳水化合物的水解和吸收从而到达有效控制餐后血糖上升的糖尿病治疗药物,具有控制餐后血糖、保护胰岛细胞功能及改善多种糖尿病并发症等作用。近10年来,α-葡萄糖苷酶抑制剂的筛选方法由传统的筛选模型迅速发展到多种新技术的应用,各种新型筛选模型不断发展应用,从天然资源中寻找新的α-葡萄糖苷酶抑制剂已成为现如今防治糖尿病的研究热点。本文对α-葡萄糖苷酶抑制剂的降糖机制及作用特点、从天然资源中筛选α-葡萄糖苷酶抑制剂的模型和方法等内容进行整理和归纳,重点对近10年来国内外从天然资源中筛选α-葡萄糖苷酶抑制剂的新型筛选模型和方法进行总结和比较,探讨各类方法的特点、存在的问题以及研究思路,为寻找和发现天然α-葡萄糖苷酶抑制剂提供基础。Alpha-glucosidase inhibitors （AGI5 are widely used in the treatment of diabetes as monotherapy and additional therapy, which play the therapeutic effect by delaying the hydrolysis and absorption of carbohydrates in the intestinal tract and effectively controlling postprandial blood glucose concentration. Alpha-glucosidase inhibitors have a variety of effects such as controlling postprandial blood glucose concentration, protecting the function of islet cell and improving the diabetic complications. In recent 10 years, the screening methods of alpha-glucosidase inhibitors have developed rapidly, a variety of new technologies have been developed and applied for screening alpha-giucosidase inhibitors from natural resources. Searching for new alpha-glucosidase inhibitors from the natural resources has become a research focus of preven- tion and control of diabetes nowadays. In the paper,the hypoglycemic mechanism, function characteristics and screening model of alpha-glucosidase inhibitors from natural resources were summarized. Different models and methods for screening alpha-glucosidase inhibitors from the natural resources both domestic and abroad in the recent years were compared. The characteristics of these methods ,the existing problems and research ideas were discussed. The work may provide the basis for searching and discovering the natural alpha-glucosidase inhibitors.

关 键 词：Α-葡萄糖苷酶抑制剂 筛选方法 

分 类 号：R284[医药卫生—中药学]