姜黄素抗肿瘤血管生成分子机制研究进展  

Advancement on effects of curcumin for molecular mechanism of anti-tumor-angiogenesis

作　　者：高文[1] 何彦津[2] 梁凤鸣[1] 

机构地区：[1]天津中医药大学第一附属医院眼科,中国天津市300192 [2]天津医科大学眼科医院,中国天津市300000

出　　处：《国际眼科杂志》2016年第3期466-468,共3页International Eye Science

摘　　要：姜黄素是从姜黄中提取的一种酚类色素,具有多种药理活性,具有抗炎、抗氧化、抗凝、降血脂、抗动脉粥样硬化、抗肿瘤、抗突变作用,其抗瘤作用机制不但与诱导肿瘤细胞凋亡相关,抗血管生成也是姜黄素抗肿瘤机制之一,主要机制为抑制血管内皮细胞增殖并促进其凋亡;抑制血管生成促进因子的表达,如通过抑制血管内皮生成因子(VEGF)及其对应受体,从而抑制肿瘤血管生成;降低基质金属蛋白酶(MMPs)的活性;通过磷脂酰肌醇-3-激酶(PI3K)信号途径抑制肿瘤血管形成:其机制为下调PI3K/AKT和促分裂原活化蛋白激酶(MAPK)途径,从而下调VEGF、Ang-1、Ang-2、VEGFR-2等。深入探讨姜黄素抗肿瘤血管生成的作用机制将为更有效的切断肿瘤血供奠定基础,有利于恶性肿瘤的防治。Curcumin as one kind of phenolic pigment extracted from dietary spice turmeric,has various pharmacological activity,which including anti- inflammatory,antioxidation,anticoagulation,hypolipidemic,anti-atherosclerotic,antineoplastic and antimutagenicity.Inducing apoptosis of tumor cells is one of the mechanisms of anti-tumor as well as anti-tumorangiogenesis.The mechanisms of anti- angiogenesis include effecting the proliferation and apoptosis of vascular endothelial cell;inhibiting the expression of angiogenesis- promoting factor,such as inhibiting vascular endothelial growth factor（VEGF） and its receptor to inhibit the formation of angiogenesis of tumor;reducing the activity of matrix metalloproteinases（MMPs） and acting through the phosphatidylinositol-3-kinase（PI3K） signaling pathway,the mechanism of which is to down-regulating the PI3K/AKT and MAPK pathways in order to down-regulating VEGF,Ang-1,Ang-2,VEGFR-2 and etc.Further research for effects of curcumin for mechanism of anti-tumor-angiogenesis will lay the foundation of more effective therapy on antitumor-angiogenesis,which is useful for prevention and treatment of cancer.

关 键 词：姜黄素 肿瘤血管生成 血管内皮生成因子 基质金属蛋白酶 磷脂酰肌醇-3-激酶 

分 类 号：R285[医药卫生—中药学]