中西医结合治疗小儿脓毒症的临床观察及对肾功能的影响  

Clinical observation of the effect of integrated traditional Chinese with Western medicine and the renal function in treating children with sepsis

作　　者：张林桃[1] 

机构地区：[1]玉环县人民医院儿科,浙江玉环317600

出　　处：《中医儿科杂志》2016年第1期58-61,共4页Journal of Pediatrics of Traditional Chinese Medicine

摘　　要：目的观察中西医结合治疗小儿脓毒症的临床疗效及对肾功能的影响。方法按照随机数字表法将本组纳入的106例患儿随机分为治疗组(n=53)和对照组(n=53)。治疗组采用中西医结合治疗,对照组单用西药治疗。治疗7 d后,评价2组患儿的疗效、治疗前后急性生理学与慢性健康状态II(APACHE II)评分变化、治疗前后白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平以及治疗前后肾功能变化。结果治疗组总有效率(96.23%)显著高于对照组(81.13%)(P<0.05),治疗组患儿治疗后APACHE II评分、IL-6和TNF-α水平显著低于对照组,差异均有统计意义(P<0.05);2组患儿治疗前后尿素氮(BUN)和血清肌酐(Scr)比较,差异均无统计意义(P>0.05)。结论中西医结合治疗小儿脓毒症临床疗效显著,可降低患儿炎症反应,并对肾功能无明显影响,具有重要的临床研究意义。Objective To investigate the clinical effect of integrated traditional Chinese with Western medicine and the renal function in treating children with sepsis. Methods According to the random number table method, 106 cases of children were randomly divided into treatment group （n=53） and control group （n=53）. The treat- ment group was treated with integrated traditional Chinese with Western medicine, and the control group was treated with western medicine alone. After 7 days treatment, the indexes of the 2 groups were analyzed from the changes of APACHE II score, IL-6 and TNF-ot, and renal function. Results The total effective rate in the treatment group （96.23%） was significantly higher than that in the control group （81.13%） （P〈0.05） ; the APACHE II score, IL-6 and TNF-α in the treatment group were significantly lower than in the control group, the difference was statisti- cally significant （ P〈0.05 ） ; the difference in Scr and BUN was not significant （ P〉0.05 ） before and after treatment in both groups. Conclusion Integrated traditional Chinese with Western medicine has significant clinical effect in treating pediatric sepsis, can reduce inflammatory reaction, but has no effect on renal function, and has important clinical significance.

关 键 词：小儿脓毒症 中西医结合 肾功能 疗效观察 

分 类 号：R515.3[医药卫生—内科学]