河南省开封市育龄妇女与婴儿麻疹抗体水平调查分析  

Analysis of Measles Antibody Level among Childbearing Women and Infants in Kaifeng City of Henan Province

作　　者：黄昌红[1] 梁月[1] 任丽君[1] 郭青艳[2] 

机构地区：[1]河南省开封市疾病预防控制中心,河南开封475000 [2]河南大学第一附属医院,河南开封475000

出　　处：《中国疫苗和免疫》2015年第6期627-630,共4页Chinese Journal of Vaccines and Immunization

基　　金：开封市科技发展计划项目(项目号130332)

摘　　要：目的了解河南省开封市育龄妇女与婴儿麻疹抗体水平,探寻高发人群麻疹免疫预防策略。方法采用酶联免疫吸附试验（ELISA）对开封市育龄妇女与婴儿进行麻疹IgG抗体水平血清学检测和统计学分析。结果 740名婴儿中麻疹IgG抗体阳性率为45.00%,抗体保护率为22.57%,抗体几何平均浓度（GMC）为91.34IU/ml。8~11月龄婴儿麻疹抗体GMC高于0~7月龄婴儿（t=5.16,P〈0.01）。0~7月龄婴儿麻疹抗体阳性率随着月龄增大而降低（χ~2=136.51,P〈0.01）,7月龄组婴儿抗体水平最低,GMC为17.41 IU/ml;而8~11月龄婴儿抗体阳性率随着月龄的增长而上升（χ~2=49.53,P〈0.01）;有含麻疹成分疫苗（MCV）免疫史婴儿抗体水平高于无免疫史（t=9.24,P〈0.01）。249名育龄妇女麻疹抗体阳性率为94.38%,抗体保护率为50.20%,GMC为694.54IU/ml;29~35岁组抗体GMC高于18~28岁组（t=5.47,P〈0.01）;有免疫史者抗体GMC低于无免疫史者（t=6.76,P〈0.01）;有患病史者抗体GMC高于无患病史者（t=13.42,P〈0.01）。结论育龄妇女、婴儿麻疹抗体水平低,需通过提高首剂MCV及时接种率、实时调整首剂MCV接种月龄及育龄妇女接种等综合免疫预防措施来推进消除麻疹工作。Objective This study is to analyze measles antibody level in infants and childbearing women and to discuss the immunization strategies for measles prevention. Methods Serum samples from child- bearing women and infants in Kaifeng were detected by enzyme linked immunosorbent assay （ELISA） for measles IgG antibodies. Results The positive rate, protective rate and GMC of measles antibody among 740 infants were 45.00%, 22.57% and 91.34 IU/ml, respectively. The antibody GMC among 8-11 month infants was higher than among 0-7 month infants （t =5.16,P 〈0. 01 ）. The positive rate of mea- sles antibody among 0-7 month infants decreased with the increase of age （X2 = 136.51, P 〈 0. 01 ） , with the lowest GMC of 17.41 IU/ml at 7 months of age; while the positive rate among 8-11 month infants in- creased with age （X2 = 49.53, P 〈 0.01 ）. The antibody GMC among infants with measles-containing vaccine （MCV） immunization history was higher than among infants without MCV history （t = 9.24, P 〈 0.01）. The positive rate, protective rate and GMC of measles antibody among 249 childbearing women were 94. 38% , 50. 20% and 694. 54 IU/ml, respectively. The antibody GMC among women aged 29-35 years was higher than among women aged 18-28 years （ t = 5.47, P 〈 0. 01 ）. The antibody GMC among women with MCV history was lower than among those without MCV history （ t = 6. 76, P 〈 0. 01 ）. The antibody GMC among women with measles history was higher than among those without measles history （t =13.42, P 〈 0. 01 ）. Conclusion The level of measles antibody was quite low in infants and childbearing women. The measles elimination should be propelled by taking comprehensive measles immunization strategies including the timely first-dose MCV immunization, the change of months of age for the first-dose MCV immunization, and the MCV immunization among childbearing women

关 键 词：麻疹 抗体 育龄妇女 婴儿 

分 类 号：R181.1[医药卫生—流行病学] R511.1[医药卫生—公共卫生与预防医学]