7．5％高渗水与20％甘露醇用于重型颅脑损伤院内急救疗效比较  

作　　者：马进[1] 严明科[1] 张曙光[1] 

机构地区：[1]江苏省昆山市第一人民医院,江苏苏州215300

出　　处：《中国药业》2015年第B12期29-30,共2页China Pharmaceuticals

摘　　要：目的比较7．5％高渗水和20％甘露醇用于重型颅脑损伤院内急救的临床效果。方法选取收治的重型颅脑损伤患者90倒，随机分为两组，各45例，即高渗水组与甘露醇组。高渗水组患者伤后进行7．5％高渗水快速推注，甘露醇组20％甘露醇静脉滴注，用药后对患者的颅内压和平均动脉压进行持续监测，观察临床疗效。结果用药后，高渗水组患者的平均动脉压和脑灌注压更高（P〈0．05），两组颅内压变化差异无统计学意义（P〉0．05）。结论重型颅脑损伤患者的院内急救，采用7．5％高渗水更有助于减轻继发性损伤，临床效果更优，值得临床推广应用。Objective To investigate the clinical effect of 7.5% high water seepage and 20% mannitol in the emergency treatment of severe traumatic brain injury.Methods 90 patients with severe traumatic brain injury were randomly divided into two groups, 45 cases in each group, namely,high water seepage group and mannitol group,20% patients were treated with 7.5% mannitol in- fusion, and the two groups were treated with continuous monitoring of intracranial pressure and peace.Results The average arte- rial pressure and cerebral perfusion pressure（P〈0.05） were higher in the two groups after treatment,and there was no significant difference between the two groups （P〉 0.05）.Conclusion 7.5% high water seepage can be used in hospital emergency treatment for severe craniocerebral injury patients,and it is helpful to reduce the secondary injury, the clinical effect is better,and it is worthy of clinical application.

关 键 词：7.5%高渗水 20%甘露醇 重型颅脑损伤 院内急救 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R977.7[医药卫生—药学]