奥美拉唑和法莫替丁治疗上消化道出血疗效对比分析  

作　　者：杨伟[1] 周军[1] 

机构地区：[1]上海市交通大学医学院附属同仁医院,上海201615

出　　处：《中国药业》2015年第B11期36-37,共2页China Pharmaceuticals

摘　　要：目的探讨并比较奥美拉唑和法莫替丁治疗上消化道出血的临床疗效。方法将2014年至2015年收治的上消化道出血患者64例随机分为治疗组和对照组，分别给予奥美拉唑和法莫替丁治疗。结果治疗组患者止血时间和输血量均优于对照组，且只有1例患者48h再出血，治疗组与对照组患者总有效率分别为93．75％和71．88％，前者显著高于后者（χ2=7．249，P=0．027）。治疗组和对照组不良反应发生率分别为3．13％和9．38％，均未出现严重不良反应。结论奥美拉唑治疗上消化道出血具有止血快速、疗效好和不良反应少等优点．值得临床推广。Objective To evaluate the clinical efficacy of omeprazole and famotidine in the treatment of gastrointestinal bleeding. Methods 64 cases with upper digestive tract bleeding were received in our hospital from 2014 to 2015,randomly divided into treatment and control groups and treated with omeprazole and famotidine,respectively.＇131en we compared clinical efficacy and ad- verse reactions of the two groups.Results Comparing to control groups,the treatment groups with shortening bleeding time and less blood transiiasion volume,and only one patient got 48h rebleeding.The total efficiency of the two groups were 93.75% and 71.88%,respectively,with significant difference （χ2=7.249,P=0.027）.Adverse reactions after treatment,adverse reactions of the treatment and control group was 3.13% and 9.38% ,all patients had no serious adverse reactions.Conclusion The treatment of omeprazole to gastrointestinal bleeding shorten bleeding time,had good efficacy and fewer adverse reactions and etc.h was worthy of clinical promotion and usage.

关 键 词：奥美拉唑 法莫替丁 上消化道出血 疗效 

分 类 号：R969.4[医药卫生—药理学] R975.2[医药卫生—药学]