阿德福韦酯治疗低病毒载量乙型肝炎相关活动性肝硬化的疗效  

作　　者：贺娜 李丽萍 王娟 郭晓明 

机构地区：[1]陕西省榆林市星元医院,陕西榆林719000

出　　处：《中国药业》2015年第B11期83-84,共2页China Pharmaceuticals

摘　　要：目的观察阿德福韦酯治疗低病毒载量乙型肝炎相关活动性肝硬化的治疗效果。方法对在我院收治的108例乙型肝炎肝硬化患者的临床资料进行回顾分析，随机分成两组，每组各54例。采用阿德福韦酯治疗为观察组，采用恩替卡韦治疗作为对照组，共治疗48周。结果观察组与对照组治疗总有效率分别为88．89％与75．93％．观察组显著更高（P〈0．05）。观察组丙氨酸氨基转移酶（ALT）水平、透明质酸（HA）水平低于对照组，总胆红素（TBIL）水平、血清蛋白（ALB）水平高于对照组（P〈0．05）；两组患者治疗后HBVDNA载量均有所下降（P〈0．05），观察纽下降程度显著高于对照组（P〈0．05）。结论对低病毒载量乙型肝炎相关活动性肝硬化患者采用阿德福韦酯治疗，效果良好，可有效缓解，临床症状，恢复肝功能，对患者生存质量提高有促进作用，可临床推广。Objective To observe the curative effect of ADEFOVIR DIPIVOXIL in the low viral load of HBV-related active hepatic cirrhosis.Method The clinical data about 108 patients with HBV-related hepatic cirrhosis in our hospital was retrospectively analyzed. The patients were randomly divided into two groups, 54 cases each group. The observation group adopted ADEFOVIR DIPIVOXIL and control group adopted Entecavir. After 48w of treatment, the clinical index of two groups was compared.Results The total effective rate of observation group （88.89%） was significantly higher than that of control group （75. 93%）（P〈 0.05）;the level of ALT and HA of observation group was lower than that of control group; the level of TBIL and ALB of observation group was higher than that of control group （P 〈 0.05）;Two groups after treatment in patients with HBV DNA loads are decreased,P〈0.05;Which the decline degree observation group is significantly higher than the control group,P〈 0.05）. Conclusion ADEFOVIR DIPIVOXIL has a favorable effect for patients with low viral load of HBV-related active hepatic cirrhosis,can effectively control and relieve the clinical symptoms,promote the recovery of liver function and improve the patient＇s quality of life.It shall be promoted in clinical practices.

关 键 词：乙型肝炎 肝硬化 低病毒载量 阿德福韦酯 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R978.7[医药卫生—药学]