植物灭螺剂螺威对大鼠的急性吸入毒性观察  

Study on acute inhalation toxicity of Luowei,a plant molluscacide

作　　者：易平[1,2] 彭程[1,2] 李爽[1,2] 

机构地区：[1]湖北省疾病预防控制中心,武汉430079 [2]应用毒理湖北省重点实验室

出　　处：《中国血吸虫病防治杂志》2016年第1期79-80,共2页Chinese Journal of Schistosomiasis Control

基　　金：国家科技支撑计划(2009BAI78B04)

摘　　要：目的观察植物灭螺剂50%螺威对大鼠的急性吸入毒性。方法20只成年Wistar大鼠,雌雄各半,通过动式吸入染毒装置给予5 000mg/m^3 50%螺威母药,染毒2 h,观察14 d内大鼠死亡与恢复情况,计算该药对大鼠的半数致死剂量(LC_(50))。结果染毒过程中大鼠活动减少,个别大鼠出现搔抓症状;染毒结束后症状消失。在染毒后14 d观察期内无大鼠死亡。螺威对雌、雄大鼠急性吸入LC_(50)均>5 000 mg/m^3,属于低毒级。结论 50%螺威母药在5 000 mg/m^3浓度下经呼吸道急性进入大鼠机体2 h,不会引起大鼠死亡,但在生产、使用该灭螺剂时仍需佩戴防护用品。Objective To study the acute inhalation toxicity of 50% Luowei, a plant molluscacide, in rats. Methods Twenty adult Wistar rats, half male and half female, were given of 5000 mg/m^3 of 50% Luowei through a dynamic inhalation device and the death and recovery of the rats were observed within 14 days, and LC50 was drawn. Results After exposure, the activities of the rats decreased and a few individual animals had scratching symptom, but the symptom disappeared after the exposure. No animals died during the whole observation period. Therefore, the acute inhalation LC50 was greater than 5000 mg/m3 for rats, and Luowei belonged to low toxicity level. Conclusions 50% Luowei will not cause animal death if it is inhaled into animal body. However, people still need to wear protective equipment in production and use.

关 键 词：螺威 植物灭螺剂 急性吸入毒性 大鼠 LC_(50) 

分 类 号：R283.24[医药卫生—中药学]