短期CPAP干预对中老年OSAHS患者血清8-OHdG、TNF-α的影响  

The effects of continuous positive airway pressure short-term treatment on 8-hydroxydeoxyguanosine and tumor necrosis factor-α levels in the serum of the middle-and advanced-aged patients with obstructive sleep apnea/hypopnea syndrome

作　　者：章婷[1] 汪俊[1] 杨晶[2] 罗荧荃[2] 

机构地区：[1]江西省人民医院呼吸内二科,南昌330006 [2]中南大学湘雅二医院老年病科,长沙410011

出　　处：《江西医药》2016年第2期95-98,105,共5页Jiangxi Medical Journal

基　　金：国家自然科学基金青年科学基金项目(30700890)

摘　　要：目的观察血清8-OHdG、TNF-α在中老年OSAHS患者中的水平变化,比较短期CPAP干预对上述指标的影响。方法随机选择确诊的23例中、重度OSAHS患者(AHI≥15次/h)作为试验组和25例(AHI<15次/h)对照者。比较两组8-OHdG、TNF-α水平及其关系,试验组随机给予连续3d CPAP干预,观察8-OHdG、TNF-α的变化。结果试验组AHI、8-OHdG、TNF-α均高于对照组(P<0.05),夜间最低SaO_2、平均SaO_2低于对照组(P<0.05)。试验组经呼吸机治疗3d后,AHI、8-OHdG、TNF-α均较治疗前降低(P<0.05),而夜间最低SaO_2、平均SaO_2则较治疗前升高(P<0.05)。所有研究对象血清中8-OHdG、TNF-α与AHI呈正相关,与最低SaO_2、平均SaO_2呈负相关(P<0.05)。8-OHdG与TNF-α呈正相关(r=0.303,P=0.037)。结论中老年OSAHS患者体内可能存在氧化应激及炎症反应,CPAP对其有改善作用。Objective To investigate whether continuous positive airway pressure （CPAP） could have an impact on levels of 8- OHdG and TNF-α in the serum of middle- and advanced-aged OSAHS patients. Methods Twenty-three patients with moderate to severe OSAHS（AHI ≥ 15 events/h） and twenty-five patients （AHI〈15 events/h） who were matched for sex,age,body mass index （BMI）and diseases as the control group were recruited. The OSAHS patients received the 3d CPAP treatment,and 8-OHdG,and TNF-αcdevels were measured. After CPAP treatment, serum 8-OHdG and TNF-αlevels were reassessed. Results The Apnea-Hypopnea Index （AHI）, 8-OHdG, TNF-α were significantly higher and the minimum arterial oxygen saturation （SaO2） and mean SaO2 significantly lower in OSAHS patients than in the control group. After the 3d CPAP treatment, 8-OHdG,TNF-α, and AHI signifi- cantly decreased in, while the minimum SaO2 and mean SaOa significantly increased in the OSAHS patients. There were significant positve Correlations between AHI and 8-OHdG ,and TNF-αand significant negative correlations between the minimum SaO2 and mean： SaO2 and 8-OHdG,and TNF-α in all subjects （P〈0.05）. There were significant positive correlations between the minimum SaO2 and mean SaO2 and between 8-OHdG and TNF-α. Conchlsion There might be oxidative stress and inflammatory responses in middle- and advanced-aged OSAHS patients. CPAP treatment has a positive effect on oxidative stress and inflammatory responses.

关 键 词：CPAP 8-OHDG TNF-Α 阻塞性睡眠呼吸暂停低通气综合征 

分 类 号：R766[医药卫生—耳鼻咽喉科]