戒烟干预联合沙美特罗替卡松粉吸入剂对COPD患者的影响  

Effects of smoking cessation intervention combined with salmeterol and fluticasone propionate powder for inhalation in patients with COPD

作　　者：叶慧娟[1] 吴继现[2] 王国菊[1] 

机构地区：[1]浙江省庆元县中医院内科,浙江丽水323800 [2]浙江省庆元县中医院急诊科,浙江丽水323800

出　　处：《重庆医学》2016年第7期888-889,892,共3页Chongqing medicine

基　　金：2013年浙江卫生厅一般项目(2013KYB276)

摘　　要：目的观察戒烟干预联合沙美特罗替卡松粉吸入剂对慢性阻塞性肺疾病(COPD)患者临床症状及肺功能的影响。方法将78例纳入研究的男性长期抽烟COPD患者进行随机分组,对照组40例,观察组38例。对照组予以茶碱缓释片、沙美特罗替卡松粉吸入剂;观察组在此基础上予以戒烟干预。观察两组患者戒烟率、症状、急性加重次数、生活评分及肺功能一秒用力呼气容积(FEV1)、用力呼气量占用力肺活量比值(FEV1/FVC)的改善情况;观察是否出现不良反应。结果两组患者症状均改善,但观察组更优,组间比较差异有统计学意义(P<0.05);患者FEV1、FEV1/FVC、急性加重次数、生活评分均较前改善,但观察组优于对照组(均P<0.05);戒烟率观察组况优于对照组(P<0.05);未发现不良反应。结论戒烟干预联合沙美特罗替卡松粉吸入剂对COPD患者疗效显著,能改善患者肺功能及症状。Objective To observe the effect of smoking cessation intervention combined with salmeterol and fluticasone propionate powder for inhalation on chronic obstructive pulmonary disease（COPD）patients with clinical symptoms and pulmonary function.Methods Totally 78 male long-term smoking cases were randomly divided into control group（n=40）and observation group（n=38）.The control group was treated with the ophylline sustained-release tablets,shah mette lo fluticasone;observation group received smoking cessation intervention.The smoking rate,symptoms,acute exacerbation,life score and lung function（FEV1,FEV1/FVC）,adverse reactions of two groups were observed.Results Two groups of symptoms were all improved,but the observation group was better（P〈0.05）.FEV1,FEV1/FVC,acute exacerbation,scores were improved,but the observation group was better（all P〈0.05）;quit rates in the observation group was better than that of the control group（P〈0.05）;and did not found adverse reactions.Conclusion The effect of smoking cessation intervention combined with salmeterol and fluticasone propionate powder for inhalation efficacy in the treatment of COPD is distinct,can improve the pulmonary function and symptoms.

关 键 词：肺疾病 慢性阻塞性 临床症状 肺功能 戒烟干预 

分 类 号：R563.9[医药卫生—呼吸系统]