HIV/AIDS合并HBV/HCV感染病毒载量水平及与T淋巴细胞相关性的探讨  

Discussing viral load levels after HIV/AIDS merges HBV/HCV infection and its relationship with T lymphocytes

作　　者：张茹薏 游晶[1] 杨微波[1] 饶少锋[1] 

机构地区：[1]昆明医科大学第一附属医院感染性疾病科,650032

出　　处：《重庆医学》2016年第7期912-914,共3页Chongqing medicine

摘　　要：目的探讨人类免疫缺陷病毒(HIV)/艾滋病(AIDS)合并乙型肝炎病毒(HBV)/丙型肝炎病毒(HCV)感染后病毒载量水平变化及对机体T淋巴细胞免疫机制的影响。方法分别测定HIV/AIDS单纯感染组,HIV/HBV合并感染组,HIV/HCV合并感染组3组的HIV RNA、HBV DNA、HCV RNA、CD4+T淋巴细胞频数、CD8+T淋巴细胞频数、CD4/CD8比值,并分析各组T淋巴细胞与HIV RNA的关系,HBV DNA/HCV RNA与HIV RNA、CD4+T淋巴细胞、CD8+T淋巴细胞、CD4/CD8比值的相关性。结果 HIV/AIDS单纯感染组、HIV/HBV合并感染组及HIV/HCV合并感染组的CD4+T淋巴细胞与各自组的HIV RNA呈负相关,差异有统计学意义(P<0.05);HIV/AIDS单纯感染组、HIV/HBV合并感染组的CD8+T淋巴细胞与各自组的HIV RNA呈负相关,差异有统计学意义(P<0.05);HIV/AIDS单纯感染组、HIV/HBV合并感染组及HIV/HCV合并感染组的CD4/CD8与各自组的HIV RNA呈负相关,差异有统计学意义(P<0.05)。结论合并感染HBV后,HIV/AIDS患者T细胞的数量下降更明显,致HIV RNA、HBV DNA高载量,加速了HIV病情进展;感染HBV后CD4+T细胞的数量下降比感染HCV更明显。Objective To explore the viral load levels after HIV/AIDS merges HBV/HCV infection and its relationship with T lymphocytes.Methods HIV RNA,HBV DNA,HCV RNA,CD4＋T lymphocyte frequency,CD8＋T lymphocyte frequency,CD4/CD8 measured in HIV/AIDS simple infection group,mixed HIV/HBV infection group and mixed HIV/HCV infection group.Analyze relationship of T lymphocyte and HIV RNA,the correlation of HBV DNA/HCV RNA,HIV RNA,CD4＋T lymphocyte frequency,CD8＋T lymphocyte frequency,CD4/CD8.Results CD4＋T lymphocyte frequency of HIV/AIDS simple infection group,mixed HIV/HBV infection group and mixed HIV/HCV infection group showed negative correlated with their respective group＇s HIV RNA（P〈0.05）;CD8＋T lymphocyte frequency of HIV/AIDS simple infection group and mixed HIV/HBV infection group showed negative correlated with their respective group＇s HIV RNA（P〈0.05）;CD4/CD8 of HIV/AIDS simple infection group,mixed HIV/HBV infection group and mixed HIV/HCV infection group show negative correlated with their respective group＇s HIV RNA（P〈0.05）.Conclusion T lymphocyte of HIV/AIDS patients drop faster,leading to high viral load of HIV RNA,HBV DNA and accelerating HIV disease progress with HBV infection.T lymphocyte of HIV/AIDS patients with HBV infection drop faster than with HCV infection.

关 键 词：肝炎病毒 乙型 肝炎病毒 丙型 HIV/AIDS HIV RNA T淋巴细胞 

分 类 号：R512.91[医药卫生—内科学] R392.3[医药卫生—临床医学]