尼莫地平柱塞型脉冲释药胶囊的制备  

Preparation of nimodipine pulsatile capsules

作　　者：李菲[1,2] 王建筑[2] 毕研平[2] 国军燕 田景振[1] 

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]泰山医学院药学院,山东泰安271016

出　　处：《中国医院药学杂志》2016年第4期296-300,共5页Chinese Journal of Hospital Pharmacy

摘　　要：目的：制备尼莫地平柱塞型脉冲释药胶囊。方法：采用灌注法制备非渗透性囊体,以HPMC K15M为缓释骨架材料制备柱塞片,以PEG6000和PEG4000为基质制备尼莫地平滴丸,用柱塞片将滴丸密封于非渗透性囊体内制备尼莫地平柱塞型脉冲释药胶囊。结果：溶剂为丙酮/二氯甲烷/乙酸乙酯（2∶0.7∶0.3）,醋酸纤维素溶液浓度为10.5%,柱塞片缓释骨架材料HPMC K15M和乳糖比例为1∶10,制得的尼莫地平柱塞型脉冲释药胶囊体外呈明显的脉冲释放,释药时滞为4~5 h。结论：通过调节柱塞片中HPMC K15M和乳糖比例可调节脉冲胶囊的释药时滞,将尼莫地平制成滴丸可满足脉冲胶囊时滞后快速释药的要求。OBJECTIVE To prepare nimodipine pulsatile capsules controlled by time. METHODS Impermeable capsule bodies were prepared using filling method, plug tablets were prepared using HPMC K15M as matrix materials. Nimodipine dropping pills were made with PEG 6000 and PEG 4000 as matrix. Pulsatile capsules were prepared by putting dropping pills in- to impermeable capsule body and sealed it with plug tablets. RF.SULTS Concentration of acetyl cellulose was 10. 5% in ace- tone/dichlormethane/ethyl acetate （2：0. 7：0. 3）, plug tablet consisted of HPMC K15M and lactose （1： 10）, and nimodipine pul- satile capsules showed obvious pulsatile release in vitro with a lag time of 4 - 5 h. CONCLUSION Pulsatile capsules with a proper lag time can be achieved by adjusting HPMC K15M/lactose ratio. Nimodipine dropping pills can meet requirements of immediate-release after the lag time of pulsatile capsules.

关 键 词：尼莫地平 脉冲胶囊 释药时滞 柱塞片 

分 类 号：R94[医药卫生—药剂学]