恩诺沙星对细胞色素P450酶系影响的研究进展  

Research Progress on Effect of Enrofloxacin on Cytochrome P450 Enzyme System

作　　者：丛琳[1,2] 武瑞[2] 李银生[1] 

机构地区：[1]上海交通大学农业与生物学院,上海200240 [2]黑龙江八一农垦大学,黑龙江大庆163319

出　　处：《畜牧与饲料科学》2016年第1期34-36,共3页Animal Husbandry and Feed Science

基　　金：国家自然科学基金项目(31172360)

摘　　要：恩诺沙星是一种抗菌药物,广泛应用于畜禽养殖业和水产养殖业。随着恩诺沙星使用量的不断增加,在其对细胞色素P450酶系的影响方面已有广泛的研究。介绍了细胞色素P450酶的基本特征,综述了恩诺沙星对细胞色素P450酶系影响的研究进展,以期为进一步阐明恩诺沙星与细胞色素P450酶系的相互作用机制及恩诺沙星在畜禽体内的药理学与毒理学特征提供理论依据。Enrofloxacin, belonging to the third generation of fluoroquinolone, is a kind of antibiotic with broad antibacterial spectrum and is widely applied in livestock and poultry breeding and aquaculture. With the increasing amount of enrofloxacin used in agriculture production, its effect on cytochrome P450 enzyme system is also widely investigated. Here we introduced the basic characteristics of cytochrome P450 enzyme and reviewed the research progress on effect of enrofloxacin on cytochrome P450 enzyme system, so as to provide reference for further understanding of interaction mechanism between enrofloxacin and cytochrome P450 enzyme system as well as pharmacologic and toxicologic features of enrofloxacin in livestock and poultry.

关 键 词：恩诺沙星 细胞色素P450酶系 P450亚酶 

分 类 号：R966[医药卫生—药理学] S859.79[医药卫生—药学]