均匀设计法优选治疣胶囊半仿生提取工艺条件  

Optimizing the Best Extraction Condition of Semi-bionic Extraction for Zhiyou Capsules by Uniform Design

作　　者：杨光义[1] 杜婷[1] 叶方[1] 李丽[2] 张晨宁[1] 魏晋宝 

机构地区：[1]十堰市太和医院湖北医药学院附属医院,湖北十堰442000 [2]湖北医药学院,湖北十堰442000

出　　处：《现代中药研究与实践》2016年第1期55-60,共6页Research and Practice on Chinese Medicines

基　　金：湖北省卫生厅2010年度中医药;中西医结合科研项目"治疣胶囊处方优化和新剂型二次开发"(2010Z-B04);2014年湖北省中青年创新团队项目(T201414;武当山区道地中药材GAP关键技术研究)

摘　　要：目的优选治疣胶囊半仿生提取工艺条件。方法以丹酚酸B、总酚酸、总黄酮含量和干浸膏收率为指标,采用均匀设计优选治疣胶囊半仿生提取工艺条件。结果优化条件为三煎用水的p H值依次为A=5.745、B=6.500、C=8.328;煎煮时间为3.079 h。结论结合生产实际,确定三煎用水的p H值依次为5.5、6.5、8.5;煎煮时间依次为1.5、0.75、0.75 h。Objective To optimize the best extraction condition of semi-bionic extraction for Zhiyou capsules. Methods The best extraction condition of the semi-bionic extraction for Zhiyou capsules by uniform design was optimized with dried extract weight and the content of salviandic acid B, phenolic acid and geniposide as the indexes, and comprehensive evaluation of each index ingredient. Results The pH values of the water are in the order of 5.745, 6.500, 8.328 and the total extraction time is 3.079 h. Conclusion Combined with the actual production, the pH values of the water are in the order of 5.5, 6.5, 8.5 and the extraction time are 1.5, 0.75, 0.75 h.

关 键 词：均匀设计 治疣胶囊 半仿生提取法 提取工艺 

分 类 号：R284.2[医药卫生—中药学]