孟鲁司特治疗过敏性鼻炎的临床疗效及安全性  

Clinical efficacy and safety of montelukast in treatment of allergic rhinitis

作　　者：张华艳[1] 雷刚[2] 

机构地区：[1]重庆市消防总队医院耳鼻咽喉科,401133 [2]重庆市中医院耳鼻咽喉科,400000

出　　处：《现代医药卫生》2016年第5期684-685,688,共3页Journal of Modern Medicine & Health

摘　　要：目的探讨孟鲁司特治疗过敏性鼻炎的安全性与有效性,为临床治疗提供一定的理论依据。方法选取2013年3月至2014年3月在该院接受治疗的116例过敏性鼻炎患者,采用随机、对照、双盲试验,根据就诊单双号将其分为观察组和对照组,各58例。观察组给予孟鲁司特钠片治疗,对照组给予安慰剂,疗程均为2周,统计两组患者的症状体征积分、疗效、生活质量评分及不良反应。结果观察组患者服用孟鲁司特后,各症状体征积分显著降低且显著低于对照组治疗后,显效率和总有效率均显著高于对照组,生活质量评分明显升高且显著高于对照组治疗后,差异均有统计学意义(P<0.05)。观察组不良反应发生率为6.9%(4/58),均较轻且未影响治疗。结论临床上应用孟鲁司特治疗过敏性鼻炎是安全、有效的。Objective To discuss the safety and effectiveness of montelukast in the treatment of allergic rhinitis so as to provide certain theoretical basis for clinical treatment. Methods Totally 116 patients with allergic rhinitis treated in our hospital from March 2013 to March 2014 were selected and divided into the observation group and the control group according to the odd and even number at visiting clinic by the random,control and double blind trial,58 cases in each group. The observation group was given the treatment of montelukast sodium tablet and the control group was given placebos. The treatment course was two weeks in the two groups. The symptom and sign scores, curative effects, qualities of life and adverse reactions in the two groups were statistically analyzed. Results The symptom and sign scores after treatment in the observation group were obviously decreased ,moreover significantly lower than those in the control group ,the significantly effective rate and the total effective rate in the observation group were significantly higher than those in the control group ,the quality of life in the observation group was obviously enhanced and significantly higher than that in the control group, and the differences were statistically significant （P〈0.05）. The incidence rate of adverse reactions in the observation group was 6.9% （4/58）, and the adverse reactions were mild without af- fecting treatment. Conclusion Montelukast is effective and safe in clinically treating allergic rhinitis.

关 键 词：鼻炎/药物疗法 乙酸盐类 喹啉类 白三烯拮抗剂 治疗结果 

分 类 号：R562.25[医药卫生—呼吸系统]