TRPV1和TRPV4通道参与缺血/氧处理心血管保护的研究进展  

Research progress of TRPV1 and TRPV4 channels in ischemia/oxygen conditioning-induced cardioprotection

作　　者：黄海燕[1] 张世忠[1] 

机构地区：[1]三峡大学医学院,湖北宜昌443002

出　　处：《药学研究》2016年第1期37-40,共4页Journal of Pharmaceutical Research

基　　金：国家自然科学基金(No.30872716);湖北省自然科学基金(No.2015CFB288);三峡大学科研创新基金(No.2015PY055)

摘　　要：TRPV通道属于瞬时受体电位(transient receptor potential,TRP)通道,含有TRPV1、TRPV2、TRPV3、TRPV4、TRPV5和TRPV6等多种亚型,它们参与机体痛觉、味觉、体温等多种生理机能的调控。近期研究发现TRPV1和TRPV4通道可能参与缺血/氧处理诱导的心肌与血管保护。TRPV1通道的作用机制可能与降钙素基因相关肽(CGRP)及P物质的释放、花生四烯酸脂氧合酶(ALOX)的表达增多有关;TRPV4通道介导的血管保护机制可能与NO和EDHF介导的内皮源性舒张有关。本文将对TRPV1和TRPV4通道在不同形式缺血/氧处理诱导下的心血管保护机制进行综述,以期为心肌缺血的治疗提供新方向。TRPV channels belong to the TRP( transient receptor potential) channel,which includes TRPV1,TRPV2,TRPV3,TRPV4,TRPV5 and TRPV6,they are involved in multiple of physiological functions including sensation of pain and taste,thermoregulation. Recent studies found that TRPV1 and TRPV4 channels may participate in ischemia/oxygen conditioning- induced cardioprotection. The cardioprotective effects of TRPV1 activation during ischemic conditioning have been linked with increased CGRP,substance P and augmented ALOX expression. Furthermore,the role of TRPV4 channels in mediating preconditioning- induced preservation of vascular function in terms restoring NO and further improving EDHF- mediated endothelial relaxation has been described. In this paper,we reviewed the TRPV1 and TRPV4 channels in mediating different forms of conditioning- induced cardioprotection along with the possible mechanisms so as to provide a new therapeutic way to myocardial ischemic.

关 键 词：心肌保护 TRPV1 TRPV4 降钙素基因相关肽 P物质 花生四烯酸脂氧合酶 

分 类 号：R541.4[医药卫生—心血管疾病]