苦参注射液联合放疗治疗老年食管癌的疗效  

Effect of matrine injection with radiation on elderly patients with Esophageal Carcinoma

作　　者：苗亚丽[1] 李晓勇 

机构地区：[1]济宁市第一人民医院,济宁272100 [2]微山县第一人民医院,济宁274200

出　　处：《天津药学》2016年第1期32-33,共2页Tianjin Pharmacy

摘　　要：目的:探讨苦参注射液联合放疗治疗老年食管鳞癌的疗效及毒性。方法:选取70例老年食管鳞癌患者,随机分为单纯放疗组(单放组)35例和苦参联合放疗组(综合组)35例。两组均采用调强放疗技术;综合组联合应用苦参注射液20 ml+氯化钠注射液250 ml,静脉滴注,1次/d,放疗全程应用。结果:两组患者疗效差别有统计学意义(P<0.05);综合组急性血液毒性及急性放射性食管炎的发生率低于单放组;两组急性放射性肺炎的发生率差异无统计学意义。结论:苦参注射液可提高老年食管癌单纯放疗的疗效,减轻放疗毒副作用。Objective： To evaluate the therapeutic and toxic effects of Matrine Injection combined with radiation on esophageal squamous cell carcinoma in the elderly patients. Methods： Senventy patients were randomly divided into two groups to receive either radiotherapy only（ Group 1,35 cases） or Matrine Injection combined with radiotherapy（ Group 2,35 cases）. Patients in both groups received intensity modulated radiotherapy（ IMRT）. In Group 2,patients were treated with Matrine Injection along with radiotherapy.Results： There was difference in therapeutic effect between the two groups. There existed statistical difference for the incidence of acute hematologic toxicity and for the incidence of radiotherapy- induced esophagitis between the two groups,while no statistical significance was found for the incidence of radiotherapy induced pneumonitis between the two groups. Conclusion： Used concomitantly with radiotherapy,Matrine Injection can enhance the efficacy of radiotherapy for elderly patients with esophageal carcinoma,and decrease the toxic side effects of radiotherapy.

关 键 词：老年食管癌 放射治疗 苦参注射液 

分 类 号：R979[医药卫生—药品]