神经肽Y在能量代谢中的研究进展  

Neuropeptide Y in Regulation of Energy Metabolism

作　　者：余慧[1] 钟文婷[1] 孙宏志[1] 

机构地区：[1]西安交通大学医学院临床病理生理研究所,西安710061

出　　处：《医学综述》2016年第5期833-837,共5页Medical Recapitulate

基　　金：国家自然科学基金(81170741);教育部新世纪优秀人才计划项目(NCET-08-0435);西安交通大学"腾飞人才"基金(N160-0710040203);西安交通大学本科生科研训练和实践创新基金(2014X15038)

摘　　要：神经肽Y是机体内一种重要的保守性生物活性肽,广泛分布于全身各处,在中枢和外周神经系统中含量最丰富。该文在介绍神经肽Y的结构、受体、合成、分布和功能的基础上,着重阐述了神经肽Y在能量代谢中所起的重要调节作用。神经肽Y通过与其受体结合发挥多种生物学效应,通过增强摄食行为和使棕脂肪组织产热减少调节能量代谢,从而导致腹部肥胖和代谢综合征。Neuropeptide Y, an important conserved bioactive peptide, is widely distributed throughout the body, especially in the central and peripheral nervous system. Based on the structure ,receptors, synthesis, distribution and functions of neuropeptide Y, here we focus on how it acts in the regulation of energy metabolism. Binding to its receptors, neuropeptide Y can stimulate food intake and reduce themogenesis of the brown adipose tissue, thus lead to abdominal obesity and metabolic syndrome.

关 键 词：神经肽Y 神经肽Y受体 能量代谢 肥胖症 代谢综合征 

分 类 号：R587.1[医药卫生—内分泌]