免疫反应在肾脏缺血/再灌注损伤中的研究进展  

Study of Immune Response in Renal Ischemia Reperfusion Injury

作　　者：陈亚楠[1] 容松[1] 

机构地区：[1]遵义医学院附属医院肾内科,贵州遵义563003

出　　处：《医学综述》2016年第5期851-854,共4页Medical Recapitulate

基　　金：国家自然科学基金(81160096)

摘　　要：缺血/再灌注损伤(IRI)是一个比较复杂的级联反应,包括血管内皮细胞、循环细胞、细胞间质和许多生化物质之间的相互作用。其中炎症反应介导的损伤是IRI的主要机制,且主要是由经典途径介导的炎症反应,中性粒细胞、巨噬细胞、补体、趋化因子等参与了IRI。另外,一些免疫细胞也参与其中,尤其是T淋巴细胞。炎症反应与细胞类型有关,并在损伤的不同时期发挥了不同的损伤或保护作用。Isehemia reperfusion injury （IRI） is a complex cascade reaction, including the interaction between vascular endothelial cells, cireulating cells, intemellular substance and many biochemical substances. The inflammatory responses mediated damage is the main mechanism of IRI,and mainly the inflammatory responses mediated by the classical pathways, such as neutrophils, macrophages, complement, chemokines and other involved in IRL Besides, seme immune cells are also involved, especially T lymphocytes. The inflammatory response is related to the cell type, playing different damaging or protective effects in different stages of the injury.

关 键 词：缺血/再灌注损伤 先天性免疫应答 适应性免疫应答 

分 类 号：R692.9[医药卫生—泌尿科学]