同步放化疗对中晚期宫颈鳞癌患者生存状况的影响  

The Effect of Concurrent Radiotherapy and Chemotherapy on Survival Status of Patients with Advanced Cervical Squamous Carcinoma

作　　者：刘怡[1] 黄明钜[1] 谭晓燕[1] 

机构地区：[1]重庆三峡中心医院妇产科,重庆404000

出　　处：《医学综述》2016年第5期1009-1011,共3页Medical Recapitulate

摘　　要：目的探讨同步放化疗对中晚期宫颈鳞癌患者生存状况的影响。方法选择2008年2月至2009年1月重庆三峡中心医院收治的126例中晚期宫颈鳞癌患者为研究对象,依据随机数字表法分为两组,放化疗组(63例)进行同步放化疗,对照组(63例)进行单纯放疗。比较两组患者的临床疗效、不良反应及1.5、3、5年生存率。结果放化疗组总有效率高于对照组[90.5%(57/63)比74.6%(47/63)],差异有统计学意义(P<0.05)。放化疗组患者的白细胞下降、血红蛋白下降、血小板下降、恶心和呕吐、血液毒性、胃肠反应的发生率均高于对照组[54.0%(34/63)比28.6%(18/63),49.2%(31/63)比17.5%(11/63),57.1%(36/63)比22.2%(14/63),66.7%(42/63)比19.0%(12/63),38.1%(24/63)比19.0%(12/63),39.7%(25/63)比15.9%(10/63)],差异有统计学意义(P<0.05)。对两组患者随访5年,放化疗组1.5、3、5年总生存率均高于对照组,差异有统计学意义(P<0.05)。结论同步放化疗治疗中晚期宫颈鳞癌成效显著,患者3、5年生存率明显升高,值得临床推广。Objective To investigate effect of the concurrent radiotherapy and chemotherapy on survival condition of patients with advanced cervical squamous carcinoma. Methods Total of 126 advanced cervical squamous carcinoma patients admitted to Chongqing Three Gorges Central Hospital from Feb. 2008 to Jan. 2009 were included as the research objects,according to random number table method they were divided into two groups：chemoradiotherapy group （63 cases receiving eoncurront chemotherapy and radiotherapy ） and control group（63 eases receiving only radiotherapy）. Clinical efficacy ,adverse reaction and 1.5,3,5 years survival rate of the two groups were compared. Results Total efficacy of the chemoradiotherapy group was higher than the control group[ 90. 5% （57/63） vs74. 6% （47/63） ] ,the difference was statistically signif- icant （ P 〈 0. 05 ）. The incidence of hemoglobin decrease, platelets decrease, nausea and vomiting, blood toxicity, gastrointestinal reactions, leukopenia of the chemoradiotherapy group were higher than the control group [ 54. 0% （34/63） vs 28.6% （ 18/63 ） ,49. 2% （31/63） vs 17.5% （ 11/63 ）, 57. 1% （36/63） vs 22. 2% （ 14/63 ） ,66. 7% （42/63） vs 19. 0% （ 12/63 ） ,38. 1% （24/63） vs 19.0% （ 12/63 ）, 39： 7% （25/63） vs 15.9% （ 10/63 ） ], the differences were statistically significant（ P 〈 0. 05 ）. Two groups were followed up for 5 years,the 1.5 years,3 years,5 years overall survival rates of the ehemoradiotherapy group were higher than the control group, the differences were statistically significant （ P 〈 0. 05 ）. Conclusion Concurrent radio-therapy and chemotherapy has significant effect for advanced cervical squamous carcinoma, which has obviously increased 3 years,5 years survival rate,thus is worth the clinical promotion.

关 键 词：宫颈鳞癌 中晚期 放化疗 不良反应 生存率 

分 类 号：R979[医药卫生—药品]