温肾解毒法治疗肾虚毒伏型HBeAg阳性慢性乙型肝炎病毒携带者临床疗效观察  

Clinical observation of Wenshen Jiedu decoction on treating chronic hepatitis B virus carriers with positive e antigen of Shenxu Dufu

作　　者：贾庆宇[1] 

机构地区：[1]唐县中医院肝胆病专科,河北保定072350

出　　处：《中西医结合肝病杂志》2016年第1期18-20,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：河北省中医药管理局中医药科研专项(No.2015309)

摘　　要：目的:观察温肾解毒法治疗肾虚毒伏型慢性乙型肝炎(CHB)病毒携带者的临床疗效。方法:105例HBV携带患者分为治疗组与对照组,治疗组给予温肾解毒法治疗,对照组给予安慰剂治疗,疗程为52周。观察两组患者治疗前后肝功能,HBeAg阴转率,HBeAg/HBeAb转换率,HBVDNA阴转率的变化。结果:治疗组有较高的HBeAg阴转率及HBeAb/HBeAg转换率、HBV DNA转阴率,具有良好的抗病毒功效,治疗前与治疗后比较有显著性差异(P<0.05);治疗组的治疗效果显著高于对照组(P<0.05)。结论:温肾解毒法治疗CHB病毒携带者的临床疗效确切,值得进一步研究。Objective： To observe the clinical of Wenshen Jiedu therapy on treating chronic hepatitis B virus carriers with positive e a- ntigen of Shenxu Dufu. Methods： 105 cases of chronic hepatitis B virus carriers were randomly divided into treatment group and control group. The treatment group were treated with Wenshen Jiedu de-coction, The control group were treated with placebo prescription, continuously for 52 weeks. Then, liver function, the seroconversion rates, the negative rates of HbeAg and the negative rates ofHBV DNA were observed be- fore and after treatment by itself. Results： The treatment group had higher rates on the negative rates of HbeAg and HBV DNA, the serocon- version rates of HBeAb/HbeAg and better treatment on HBV. The difference was statistically significant in the treatment group before and after treatment（P〈0.05） ; The treatment group was superior to the control group （P〈0.05）. Conclusion： The Wenshen Jiedu therapy was a good treatment on chronic hepat-itis B virus carriers and it worth to be popularized in clinical.

关 键 词：乙型肝炎病毒携带者 慢性 HBEAG阳性 肾虚毒伏 温肾解毒 中医药疗法 临床观察 

分 类 号：R259[医药卫生—中西医结合]