低剂量免疫球蛋白联合糖皮质激素治疗妊娠合并血小板减少疗效观察  

Effects of Low Dose Immunoglobulin Combined with Glucocorticoid in the Treatment of Pregnancy Associated with Thrombocytopenia

作　　者：吴春农[1] 宋光彩[1] 张杰[1] 

机构地区：[1]凉山彝族自治州第一人民医院血液科,四川西昌615000

出　　处：《四川医学》2016年第1期68-70,共3页Sichuan Medical Journal

摘　　要：目的观察静脉低剂量输注人血免疫球蛋白联合口服低剂量糖皮质激素(泼尼松)治疗妊娠合并重度血小板减少症患者的疗效。方法选择我院妊娠合并血小板减少(血小板计数低于30×109/L)患者40例,随机分为两组,治疗组19例,对照组21例。治疗组给予人血免疫球蛋白2.5g,每周输注1次,同时口服泼尼松20mg/d;对照组仅给予泼尼松30mg/d口服。每周复查血常规1次,连续8周,观察血小板上升情况。结果人血免疫球蛋白治疗组患者血小板上升明显快于单纯口服泼尼松组,差异有统计学意义(P<0.05)。无1例发生产时、产后出血及新生儿颅内血肿。结论低剂量免疫球蛋白联合糖皮质激素治疗妊娠合并血小板减少较单用糖皮质激素可以更快捷,安全提升患者血小板。Objective To observe the effect of intravenous low dose injection of human immunoglobulin combined with o- ral low dose glucocorticoid（prednisone） in the treatment of pregnancy associated with severe thrombocytopenia patients. Methods 40 patients chosen from our hospital with pregnancy associated with thrombocytopenia（ platelet count was less than 30 x 109/L） , were divided into 2 groups randomly, 19 cases in treatment group, 21 cases in control group. Treatment group was given human immunoglobulin 2.5G, a week once injection and oral poured prednisone 20rag/d, while the control group was only received oral prednisone （30rag/d） , once weekly review of blood, lasting 8 weeks, and was observed the effect of platelet rise. Results Plate- let rise in patients from the human immunoglobulin treatment group was obviously faster than simply oral prednisone group （ P 〈 0. 05 ） , no 1 case of production, postpartum hemorrhage and neonatal intraeranial hematoma. Conclusion Low dose immuno- globulin combined with glucocorticoid in the treatment of pregnancy associated with thrombocytopenia was more rapid than the sin- gle use of glucocortieoid, safe to enhance the platelet.

关 键 词：免疫球蛋白 糖皮质激素 妊娠 血小板减少 

分 类 号：R714.254[医药卫生—妇产科学]