MicroRNA-122结合区遗传变异IL-1A rs3783553与慢性HBV感染的关联研究  

Association of Genetic Variant rs3783553 at MicroRNA122-binding Site in IL-1A Gene with Risk of Chronic HBV Infection

作　　者：陈雪琴[1,2] 王英[3] 娄娇[1] 杨洋[1] 龚雅洁[1] 朱颖[1] 向成[4] 钟荣[1] 

机构地区：[1]华中科技大学同济医学院公共卫生学院流行病与卫生统计学系,武汉430030 [2]江西省肿瘤医院质控科,南昌330029 [3]武汉市疾病预防控制中心病毒科,武汉430015 [4]华中科技大学同济医学院附属同济医院检验科,武汉430030

出　　处：《华中科技大学学报（医学版）》2016年第1期53-55,69,共4页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：中国博士后科学基金资助项目(No.2014M550395);武汉市创新人才开发基金资助项目

摘　　要：目的探讨白细胞介素-1A（IL-1A）基因3′UTR区遗传变异rs3783553与慢性乙型肝炎病毒感染风险的关联。方法采用病例对照研究,选取慢性乙肝病毒感染的病例1 271例,自发性乙肝病毒清除者1 298例。采用ABI7900HT的TaqMan基因分型技术对遗传变异位点进行检测;采用χ2检验和t检验比较病例组和对照组间人口学特征分布差异,应用非条件Logistic回归分析rs3783553对慢性乙肝病毒感染风险的影响。结果遗传变异位点rs3783553插入（TTCA）等位基因携带者发生慢性乙肝病毒感染风险显著低于缺失等位基因携带者（OR=0.71,95%CI=0.61~0.84）。每增加1个插入等位基因,携带者患慢性乙肝病毒感染的风险降低21%（OR=0.79;95%CI=0.70~0.89）。结论IL-1A基因3′UTR区的遗传变异位点rs3783553与慢性乙肝病毒感染的风险有显著关联。Objective To explore the association of the genetic variant rs3783553 in IL-1A3′UTR with the risk of chronic HBV infection.Methods In this case-control study,genetic variant rs3783553 was genotyped by TaqMan PCR genotyping method in 1 271 patients with chronic HBV infection and 1 298 subjects with HBV natural clearance.χ2test and t test were employed to compare the distribution difference of demographic characteristics between case and control groups.The contribution of rs3783553 to chronic HBV infection was analyzed by unconditional Logistic regression.Results Carriers with TTCA insertion allele of rs3783553 were less likely to develop chronic HBV infection than those with deletion allele（OR=0.71;95%CI=0.61-0.84）.With one increment of insertion allele,the risk of chronic HBV infection decreased by 21%（OR=0.79;95%CI=0.70-0.89）.Conclusion Genetic variant rs3783553 in IL-1A3′UTR is closely associated with the risk of chronic HBV infection.

关 键 词：rs3783553 慢性乙型肝炎病毒感染 病例对照研究 

分 类 号：R512.6[医药卫生—内科学]