慢性鼻-鼻窦炎患者药物治疗的生存质量及相关研究  

Investigation of quality of life on chronic rhinosinusitis following medication

作　　者：吴青松[1] 曾蓉[1] 刘明娜[1] 洪潮鑫[2] 刘绪光[1] 邓伟锋[1] 周凤平[1] 

机构地区：[1]深圳市龙岗区人民医院耳鼻喉科,广东深圳518172 [2]深圳市龙岗区人民医院信息科,广东深圳518172

出　　处：《山东大学耳鼻喉眼学报》2016年第1期26-30,共5页Journal of Otolaryngology and Ophthalmology of Shandong University

基　　金：深圳市科技计划项目(201203322);深圳市龙岗区科技局资助项目(YS2012085)

摘　　要：目的使用鼻窦炎症状视觉模拟量表(VAS)及鼻窦炎专用量表-鼻腔鼻窦结局测试20(SNOT-20)中文版评价慢性鼻-鼻窦炎患者药物治疗前与治疗后不同时间的生存质量(QOL),探讨药物治疗对患者QOL的影响。方法收集慢性鼻-鼻窦炎患者100例作为实验组,给予药物联合治疗12周,每4周进行一次VAS评分及SNOT-20评分。另收集100例健康体检者作为对照组,进行一次相同的评分。分析实验组治疗前后及停药后患者VAS评分、SNOT-20评分的变化及与对照组的差异。结果实验组治疗前后及停药后VAS评分差异具有统计学意义(F=38.39,P<0.01)。实验组治疗12周后与对照组VAS评分比较差异具有统计学意义(t=7.93,P<0.01)。实验组VAS、CT评分于治疗后5个症状占比分别有所下降,每种症状的VAS、CT评分也有所下降。实验组治疗前后及停药后SNOT-20评分经单因素方差分析显示差异具有统计学意义(F=27.93,P<0.01)。实验组治疗12周后与对照组SNOT-20评分比较差异具有统计学意义(t=19.93,P<0.01)。实验组于治疗后各症状占比人数分别有所下降,每种症状的SNOT-20评分也有所下降。结论药物治疗作为慢性鼻-鼻窦炎的首选治疗方式,可有效改善患者的QOL,但长期小剂量使用的远期疗效尚有待进一步证实。Objective To evaluate chronic rhino-sinusitis medication before treatment and quality of life （QOL） at dif- ferent times after treatment and to investigate the drug therapy on QOL of patients. Methods Using sinusitis symptom visual analog scale （VAS） and sinusitis special scale-sinonasal outcome Test 20 （SNOT-20）, we collect 100 patients with chronic rhinitis-sinusitis as the experimental group receiving 12 weeks combination therapy drugs, once every four weeks, and another 100 healthy volunteers as the control group. Results By univariate analysis, the VAS score showed a significant difference （F = 38. 39, P 〈 0.01 ） before and after treatment in the experimental group, and it showed a significant difference （ t --7.93, P 〈0.01 ） between the 12-week after treatment group and the control group; After the drug treatment, VAS and CT score of 5 symptoms accounted decreases and each symptom rate also declined. By univariate analysis, the SNOT-20 score also showed a significant difference （F = 27.93, P 〈 0.01 ） before and after treatment in the experimental group, and it showed a significant difference （t = 19.93, P 〈 0.01 ） between the 12-week after treatment group and the control group ; After the drug treatment, patents with each symptom accounted decrease and each symptom rate also declined. Conclusion Drug treatment can effectively improve the QOL chronic rhinitis sinusitis, whether needing long-term low-dose use remains further confirmation.

关 键 词：慢性鼻-鼻窦炎 药物治疗 生存质量 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]