短期布地奈德混悬液经鼻雾化对慢性鼻窦炎伴鼻息肉手术出血的影响  

Effect of short-course budesonide suspension via nasal atomization on the operation bleeding of chronic nasosinusitis accompanied by nasal polyps

作　　者：郭艳红[1] 马莎[1] 王济生[1] 

机构地区：[1]新乡市中心医院耳鼻咽喉科,河南新乡453000

出　　处：《山东大学耳鼻喉眼学报》2016年第1期51-53,共3页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的评价短期应用布地奈德混悬液经鼻雾化对慢性鼻窦炎伴鼻息肉手术出血的影响。方法 96例慢性鼻窦炎伴鼻息肉患者随机分成A组33例、B组31例及C组32例,A组术前7 d给予布地奈德混悬液经鼻雾化吸入及罗红霉素口服,B组给予布地奈德喷鼻剂喷鼻及罗红霉素口服,C组给予生理盐水鼻腔冲洗及罗红霉素口服。三组均在全麻气管插管下按统一方案手术。对比三组术中出血量及A、B组血清皮质醇浓度变化。结果 A、B、C三组患者术中平均出血量分别为(51.70±18.62)m L、(73.16±19.23)m L、(90.16±15.97)m L,三组间差异有统计学意义(F=37.34,P<0.01)。A组用药后血清皮质醇浓度降低(P<0.01),但在正常值范围内;B组用药前后血清皮质醇浓度无变化(P>0.05)。结论短期应用布地奈德混悬液经鼻雾化吸入,可减少慢性鼻窦炎伴鼻息肉患者鼻内镜术中出血,且对肾上腺皮质功能无明显影响。Objective To evaluate the effect of short-course budesonide suspension via nasal atomization on the opera- tion bleeding of chronic nasosinusitis accompanied by nasal polyps. Methods A total of 96 patients with chronic naso- sinusitis accompanied by nasal polyps were randomly divided into group A （n = 33 ）, group B （n = 31 ） and group C （ n = 32）. At 7 days before the operation, group A was inhaled budesonide suspension via nasal atomization and took roxithromycin ; Group B was given budesonide nasal spray and took roxithromycin; Group C was given normal saline to wash the nasal cavity and took roxithromycin. The operations were performed in 3 groups according to the unified regi- men. The amount of intraoperative bleeding in 3 groups and change of serum corfisol concentrations in groups A and B were compared. Results Average amount of intraoperative bleeding in 3 groups was （51.70± 18.62） mL, （73.16 ± 19.23 ） mL and （90.16± 15.97） mL, and there was statistical significance among 3 groups （ F = 37.34, P 〈 0.01 ）. The concentration of serum cortisol in group A decreased after administration （ P 〈 0.01 ）, but it was still within the normal range ; There was no change in group B regarding the concentration of serum cortisol before and after administra- tion （ P 〉 0.05 ）. Conclusion Short-course application of budesonide suspension via nasal atomization can reduce en- doscopic intraoperative bleeding of patients with chronic nasosinusitis accompanied by nasal polyp and has no obvious impact on the function of adrenal cortex.

关 键 词：鼻窦炎 鼻息肉 布地奈德 鼻内镜外科手术 

分 类 号：R765.2[医药卫生—耳鼻咽喉科]