丹参多酚酸体内吸收、分布、代谢、排泄研究进展  

ADME Research Progress on Salvianolic Acids in Vivo

作　　者：张娜[1,2] 王鹏[1] 潘桂湘[1] 王晓明[1] 张家伟[1,2] 侯艳婷[1,2] 

机构地区：[1]天津中医药大学,天津市现代中药重点实验室-省部共建国家重点实验室培育基地,天津300193 [2]天津国际生物医药联合研究院,天津300457

出　　处：《辽宁中医杂志》2016年第2期436-440,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家重大新药创制项目(2012ZX09101202);国家重点基础研究发展(973计划)项目(2012CB723504)

摘　　要：丹参多酚酸是丹参的主要活性部位之一,含有丹参素、丹酚酸B、丹酚酸A、迷迭香酸、紫草酸、丹酚酸C、丹酚酸D等成分。文章总结了近年来丹参多酚酸的体内药代、药动研究报道,对其吸收(absorption)、分布(distribution)、代谢(metabolism)、排泄(excretion)即ADME过程进行综述,有助于了解丹参多酚酸在体内的存在形式与暴露程度,为更好地围绕活性成分进行丹参药材/制剂的质量控制,或新剂型开发等提供参考。As the main active compound of Salviae Miltiorrhizea,Salvianolic acids consist of dansensu,rosmarinic acid,lithospermic acid,salvianolic acid A,salvianolic acid B,salvianolic acid C and salvianolic acid D etc. In this article,we give a summary on extensive studies of salvianolic acids in terms of pharmacokinetics over the recent years. To do that,we have reviewed absorption,distribution,metabolism and excretion（ ADME） of salvianolic acids. All those efforts will contribute to a better understanding of exiting forms and exposed levels of salvianolic acids in vivo and provide a stricter quality control over active constituents in Materia Medica or preparation of Salviae Miltiorrhizea. Meanwhile,we can further develop its new dosage forms based on the information we made.

关 键 词：丹参多酚酸 ADME 药代 药动 

分 类 号：R284.1[医药卫生—中药学]